Original articleGeneral thoracicLong-Term Survival in Bilateral Lung Transplantation for Scleroderma-Related Lung Disease
Section snippets
Study Design
We retrospectively reviewed our clinical database, including all lung transplant recipients who underwent transplant between January 1, 2008, and December 31, 2014, at the Houston Methodist Hospital. We identified all patients who underwent a bilateral lung transplant. We included only those recipients with a diagnosis of group D restrictive lung disease. For classification purposes, all scleroderma patients were listed in our database as group D restrictive disease, including those with
Results
Demographic data are reported in Table 1. From 2008 to 2014, our institution performed 684 lung transplants, including 394 bilateral transplants. Of that cohort, 181 met our criteria for inclusion into the analysis, with 26 scleroderma patients and 155 nonscleroderma group D restrictive disease patients (Fig 1).
Several differences were noted between the cohorts at baseline. The scleroderma patients tended to be younger, and the percentages of women and African-American patients were higher.
Comment
Although lung transplantation has been established as a safe and effective treatment for a variety of etiologies of end-stage lung disease, patients with scleroderma are still frequently declined for fear of their overall risk profile. This patient population has been a challenging one to study for several reasons. Scleroderma is a rare disease process that accounts for 1.4% of those undergoing lung transplantation [11], so previous research has mostly involved small case series from
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