Original articleGeneral thoracicExtrapleural Pneumonectomy After Induction Chemotherapy: Perioperative Outcome in 251 Mesothelioma Patients From Three High-Volume Institutions
Section snippets
Patients and Methods
The present retrospective analysis of 251 MPM patients was set up in a three-institutional setting and included the results of the outcome in MPM patients at the University of Zurich (cohort 1, n = 137), the Division of Thoracic Surgery at the University of Toronto (cohort 2, n = 60), and the University of Vienna (cohort 3, n = 54) from 1999 until 2012. Approval of the institutional review board and patient consent was obtained in all three centers. The MPM patients underwent mostly three
Results
Between 1999 and 2012, a total of 251 patients underwent platinum-based induction chemotherapy followed by EPP at the three different institutions. The characteristics of the three cohorts are shown in Table 1. Significant differences between all cohorts were observed in the distribution of gender (Fisher’s exact test, p = 0.02), body mass index (independent samples Kruskal-Wallis test, p = 0.006), smoking habits (Fisher’s exact test, p < 0.0005), pulmonary function test (independent samples
Comment
In this retrospective analysis, we demonstrated that perioperative morbidity and mortality of EPP after induction chemotherapy in 251 consecutively treated patients in three dedicated centers for mesothelioma research and treatment could be maintained with an acceptable rate. Regarding the trend of the past 14 years, there was no obvious learning curve comparing early with late periods, but indeed fewer patients died during the early postoperative phase, and in one center (cohort 1) no patient
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Drs Lauk and Hoda contributed equally to this work.