Elsevier

Annals of Medicine and Surgery

Volume 60, December 2020, Pages 413-416
Annals of Medicine and Surgery

Comparison of efficacy of dexamethasone and methylprednisolone in moderate to severe covid 19 disease

https://doi.org/10.1016/j.amsu.2020.11.027Get rights and content
Under a Creative Commons license
open access

Highlights

  • First head to head comparison between two corticosteroids dexamethasone and methylprednisolone in covid 19 disease.

  • Multicentre study from Pakistan.

  • Data collected during peak of covid 19 pandemic.

  • Both dexamethasone and methylprednisolone are equally effective in treating moderate to severe covid 19.

Abstract

Background

The first case of Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were diagnosed in Wuhan, China in 2019. In the first half of 2020 this disease has already converted into a global pandemic. Various treatment options were being tried all over the world. Some studies showed beneficial effects of corticosteroids in covid 19. Hence, we designed this study to compare the effect of two steroids in moderate to severe covid 19 disease.

Objectives

To compare the efficacy and safety of dexamethasone and methylprednisolone in moderate to severe covid 19 disease.

Study Settings

Fatima Memorial Hospital, Lahore and Ganga Ram hospital, Lahore.

Study Design

Quasi experimental, interventional study.

Duration of Study

From 1st June 2020 to 30th June 2020.

Methodology

Sample size and technique: there were total 100 patients; 35 patients received dexamethasone and 65 were kept in methylprednisolone receiving group.

Results

The mean age of patients was 57.91 years in dexamethasone group and 54.86 years in methylprednisolone group. In dexamethasone group, there were 15 (42.8%) critically ill patients who were shifted to Intensive care unit (ICU) and seven (20%) of them needed ventilatory support, whereas in methylprednisolone group 22 (33.8%) had to be admitted in ICU with eight (12.3%) patient needing ventilator. As outcome measure, patients in both the groups showed marked improvement in temperature, oxygen requirement and C-reactive protein (CRP) on day 5. Only six (17.1%) patient died who received dexamethasone while 10 (15.3%) patients died among those receiving methylprednisolone.

Conclusion

Dexamethasone and methylprednisolone both are equally effective in treating moderate to severe covid 19 disease.

Keywords

Covid 19 disease
Corticosteroids
Methylprednisolone
Dexamethasone

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