The impact of obesity on treatment choices and outcomes in operable breast cancer
Section snippets
Background
Breast cancer is the most common cancer in the United States with approximately 12.4% of US women being diagnosed during their lifetime.1 Obesity has been linked to an increased risk of developing hormone-receptor positive breast tumors with some studies demonstrating up to a 52% increase in the risk of developing hormone receptor positive breast cancers in post-menopausal women with obesity. The increased risk in post-menopausal obese women is thought to be due to increased levels of aromatase
Materials and methods
The study was conducted as a retrospective review of consecutive patients with invasive breast cancer diagnosed between 2009 and 2012. This was conducted within a single institution, Spectrum Health, at the Butterworth and Blodgett Campuses. The study obtained approval from the Institutional Review Board with a waiver of informed consent.
Demographics
There were 1566 patients included for study, of which 596 (38%) were obese. The groups were equivalent for nulliparity, tumor histology, grade, nodal disease, lymphovascular invasion, and hormone receptor status. Obese patients were older with a higher incidence of comorbidities including hypertension, DM, hyperlipidemia and hypothyroidism. Obese patients were also more likely to present with stage II breast cancer. Please see Table 1 for further information on demographics and tumor
Discussion
The rate of obesity in the United States has been steadily increasing over the past several decades. In the wake of this epidemic, it is important to understand the impact of obesity on the treatment and outcomes of other diseases. We sought to examine the impact of obesity on a large consecutive cohort of patients with invasive breast cancer.
Obese patients in our study were more likely to undergo breast conserving surgery than non-obese patients. This is important as mastectomy rates increase
Conflict of interest disclosures
The authors have no disclosures.
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10-Year Survival after Breast-Conserving Surgery Compared with Mastectomy in Louisiana Women with Early-Stage Breast Cancer: A Population-Based Study
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The Effect of Obesity on Operating Room Utilization in Breast Surgery
2021, Journal of Surgical ResearchCitation Excerpt :The continual rise in BMI has been impacting patient health, changing medical practice, and affecting the cost of health care. Many studies analyzing the effects of obesity on surgery have focused on the increase in health care costs related to obesity-related comorbidities such as diabetes and heart disease,2-4 whereas others have focused associated complications including surgical site infections, length of stay, and so forth.4-8 Few studies have explored the effect of obesity on surgical procedure time which could potentially impact operating room (OR) utilization.
The relationship between post-surgery infection and breast cancer recurrence
2020, Journal of Hospital InfectionCitation Excerpt :Following examination of full texts and application of appropriate exclusion based on the aforementioned criteria, searches that focused on SSI characteristics following primary breast cancer surgery yielded 899 studies, of which 99 [21–60] [61–100] [101–119] were eventually included in this arm of the review. For the cancer recurrence focused search, 554 papers were screened and 44 [15,16,23,59,78,82,93,104], [22,33,95,120–152] were included in the data extraction, as depicted in Figure 1. The screen also identified two systematic reviews [153,154] from which nine papers were found to be eligible for inclusion [155–163].
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