Clinical research studySerum Uric Acid Levels and the Risk of Type 2 Diabetes: A Prospective Study
Section snippets
Study Population
We conducted analyses of the prospectively collected data in the Framingham Heart Study original and offspring cohorts, using the datasets obtained from the National Heart, Lung and Blood Institute (NHLBI). The Framingham Heart Study–original cohort is an ongoing longitudinal study of 5209 men and women from the town of Framingham, Massachusetts, aged 29-62 years at time of recruitment in 1948. Subjects have been followed biennially, with data from a detailed medical history, a physical
Results
The baseline characteristics of original and offspring cohorts are shown in Table 1. The mean baseline ages were 45 years in the original cohort (45% men) and 37 years in the offspring cohort (48% men).
We identified 641 incident type 2 diabetes cases (320 men) in the original cohort over a 28-year median follow-up, and 497 incident cases (287 men) in the offspring cohort over a 26-year median follow-up. In both cohorts, the incidence of type 2 diabetes increased with increasing serum uric acid
Discussion
In this prospective study of two generations of the Framingham Heart Study, we found that higher levels of serum uric acid were associated with an increasing risk of developing type 2 diabetes. Specifically, for every mg/dL increase in serum uric acid level, the risk of type 2 diabetes was increased by 20% in the original cohort and 15% in the offspring cohort. These associations persisted in both sexes and were independent of other known risk factors of type 2 diabetes, including age, BMI,
Acknowledgment
The authors thank the Framingham Heart Study coordinators for access to the dataset. The Framingham Heart Original and Offspring studies are conducted and supported by the NHLBI in collaboration with the Framingham Heart Study Investigators. This manuscript has been reviewed by the NHLBI before submission for publication. NHLBI had no role in the design, conduct, analyses, and reporting of the study or in the decision to submit the manuscript for publication. The authors would also like to
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Funding: This work was supported in part by grants from the National Institutes of Health (AR047785). Dr. Bhole receives postdoctoral training fellowship support from the Canadian Arthritis Network/The Arthritis Society of Canada. Ms. De Vera receives training support from the Canadian Arthritis Network/The Arthritis Society of Canada, the Michael Smith Foundation for Health Research, and the Canadian Institutes of Health Research.
Conflict of Interest: Dr. Choi has received research funding from Takeda Pharmaceuticals North America Inc. for an unrelated project. No conflicts of interest for any of the authors.
Authorship: All authors had access to the data and were involved in drafting the article and revising it critically for important intellectual content.