CardiomyopathyPredictors of Short- and Long-Term Outcomes of Takotsubo Cardiomyopathy
Section snippets
Methods
Fifty-six consecutive patients presenting to a single urban medical center with TC comprised the study group. The Institutional Review Board approved the study protocol and data analysis. No external funding was used for this study. The International Classification of Diseases, Ninth Revision (ICD code 429.83), was used to identify patients, aged ≥18 years, who were discharged with a diagnosis of TC. The charts of identified patients who presented from 2004 to 2014 were reviewed for the
Results
The clinical characteristics of the study patients are listed in Table 1. Intubation and mechanical ventilation occurred in 10.7% of subjects. Deep T-wave inversion was the most common abnormal finding on electrocardiography (57.1%). ST elevation was also noted in 7 patients (12.5%). Mean initial LVEF was 33.2 ± 7.9% and 57.6 ± 7.4% for repeat LVEF. Mean time to repeat echo was 21.6 ± 37.6 weeks. Mean troponin (6.47 ± 13.57) was elevated in all patients. Mean length of stay was 8.7 ± 8.1 days (
Discussion
This is the first clinical series demonstrating prognostic significance of QTc prolongation at presentation in TC. Because the cause of TC involves intense catecholamine release and hyperadrenergic tone, the QTc may reflect the individual impact on myocardial repolarization and sympathetic innervation, explaining its prognostic significance. In this series, TC was associated with an 8.9% in-hospital mortality, an additional 17.9% mortality after discharge (despite improvement in LV function),
Disclosures
The authors have no conflicts of interest to disclose.
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2024, Journal of Cardiology CasesEffect of β-Blocker Use on Long-Term Mortality in Takotsubo Cardiomyopathy: A Systematic Review and Meta-Analysis
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2023, International Journal of CardiologyElectrocardiographic Characteristics and Associated Outcomes in Patients with Takotsubo Syndrome. Insights from the RETAKO Registry
2021, Current Problems in CardiologyCitation Excerpt :The prevalence in our cohort was 61%, slightly higher than in previous studies, but a large variation among series has been observed.15,17,34 Prolongation of corrected QT interval is frequently present in TTS and predisposes to adverse events, characteristically malignant ventricular arrhythmia and sudden cardiac death.35-38 Previous work regarding prognostic factors of TTS has focused in clinical, echocardiographic, or hemodynamic factors, and less attention has been paid to electrocardiographic features.4,8,18
Electrocardiographic changes in Takotsubo cardiomyopathy
2021, Journal of ElectrocardiologyPredictors of 90-Day Readmission and in-Hospital Mortality in Takotsubo Cardiomyopathy: An Analysis of 28,079 Index Admissions
2019, Cardiovascular Revascularization MedicineCitation Excerpt :Murugiah et al. have shown that 1 in 10 patients was readmitted within 30 days, and our study shows that 1 in 4 patients will be readmitted within 90 days, which is similar to the study done by Shah et al. [14] and higher than readmissions after ACS [15]. Acute heart failure/recurrent takotsubo cardiomyopathy is the most common cardiac cause for readmission at 1.8% (n = 512), which is similar to the previously published studies [14,16]. The strongest predictors of readmission were found to be age, heart failure at baseline, chronic pulmonary disease, diabetes mellitus, peripheral vascular disease, and gender.
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