Arrhythmias and conduction disturbancesAtrial Substrate Properties and Outcome of Catheter Ablation in Patients With Paroxysmal Atrial Fibrillation Associated With Diabetes Mellitus or Impaired Fasting Glucose
Section snippets
Methods
Bi-atrial electroanatomic mapping using a 3-dimensional mapping system (NavX, St. Jude Medical, St. Paul, Minnesota) was performed in 228 consecutive patients (age 52.3 ± 12.6 years, 167 men) with symptomatic drug-refractory paroxysmal AF. An abnormal glucose metabolism was defined as DM or an impaired fasting glucose, which was diagnosed according to the American Diabetes Association criteria.11 A total of 65 patients (28.5% of the study population) were included in the abnormal glucose
Results
The baseline characteristics of the study patients are listed in Table 1. The mean age of the study population was 52.3 ± 12.6 years (range 20 to 85). Of the 228 patients, 167 were men and 61 were women. Of the study population, 29% had hypertension, 14% dyslipidemia, and 20% coronary artery disease. The AF duration was 4.5 ± 4.0 years. No significant differences were found in the distribution of men, underlying disease, medications used, lipid profile, or AF duration between the 2 groups. The
Discussion
In the present study, we investigated the electrophysiologic properties of the biatrial substrate and outcome after catheter ablation in patients with paroxysmal AF and a normal or an abnormal glucose metabolism. To the best of our knowledge, this study is the first to investigate the relation between an abnormal glucose metabolism and the atrial substrate. The main findings were as follows. First, patients with an abnormal glucose metabolism, including those with DM and those with an impaired
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Drs. Tze-Fan Chao and Kazuyoshi Suenari contributed equally to their work.