Original ResearchObstetricsFertility treatments and pediatric neoplasms of the offspring: results of a population-based cohort with a median follow-up of 10 years
Section snippets
Methods
A population-based cohort analysis was performed that included all singleton infants born during the years 1991–2013 and discharged alive from Soroka University Medical Center (SUMC). SUMC includes the largest birth center in Israel and is the only tertiary hospital in Israel’s southern region and the single IVF unit in the region. In Israel all fertility interventions, which includes IVF, are covered fully by a national health law (1997), which allows citizens of all backgrounds access to
Results
During the study period, 242 187 newborn infants met the inclusion criteria: 2603 of whom (1.1%) were conceived after IVF; 1172 of whom (0.7%) were conceived after OI, and 237,863 of whom (98.3%) were with pregnancies that were conceived spontaneously. The rates of IVF have changed from 0.2% of the offspring in 1991 to 1.8–2.0% in the years 2012–2013; OI rates were 1.0% (1991) and 0.5% (2013). Table 1 presents background information of the study population, which includes demographic,
Comment
In this large population-based study with a long follow-up period, children who were conceived via fertility treatments, specifically those who were conceived via IVF, were found to be at an increased risk for future pediatric neoplasms compared with spontaneously conceived children. Moreover, this association was found to be independent of several important perinatal characteristics such as gestational age and birthweight. The low rates of fertility treatments and IVF specifically can be
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Epigenetics and mental and physical health of children born after ART
2023, Sex, Gender, and Epigenetics: From Molecule to BedsidePossible association between in vitro fertilization technologies and offspring neoplasm
2021, Fertility and SterilityCitation Excerpt :Among mothers, most recent studies did not find associations between IVF treatments and neoplasms, yet results were less consistent among offspring. Several previous studies, including a meta-analysis, have found an overall increase in the probability of childhood cancers after fertility treatments were performed (28–30, 32, 34, 35), yet other studies have not found such an association. Among the studies in which an association was found, specific cancer types were noted such as Hodgkin’s lymphoma, leukemia, and central nervous system tumors (23, 24, 27).
The association between fertility treatments and the incidence of paediatric cancer: A systematic review and meta-analysis
2020, European Journal of CancerCitation Excerpt :Then, two authors excluded 1574 substandard papers after reading titles and abstracts independently and excluded 29 other substandard studies after reading full texts independently; these comprised different papers by the same authors with repetitive data. In the end, 27 studies [4–11,16–34] were included in this systematic review and meta-analysis, including 11 case–control studies and 16 cohort studies (Fig. 1). The included studies were divided into four categories (containing repetitive papers) in accordance with the types of fertility treatments (IVF, ICSI, fertility drugs and frozen embryo transfer).
Long-term endocrine disorders in children born from pregnancies conceived following fertility treatments
2020, Early Human DevelopmentCitation Excerpt :Short-term consequences of fertility treatments include adverse perinatal outcome, including perinatal morbidity and mortality, as well as congenital malformations [7–9]. Recently, several studies found higher rates of long-term morbidity in offspring conceived following fertility treatments, including infectious [10], neurological [11], gastrointestinal [12], respiratory, obstructive sleep apnea [13], oncological [14], and dermatological morbidities [15]. Many endocrine disorders, caused by a variety of genetic and acquired conditions, can lead to female infertility.
Fertility treatments and gastrointestinal morbidity of the offspring
2020, Early Human DevelopmentCitation Excerpt :Previously reported long term complications comprise of higher probability of hospitalization [11], asthma [12], metabolic and cardiovascular disorders [13]. Some long term complications like risk of pediatric neoplasms [14], and skin eruption [15] are still controversial. The data regarding the association between fertility treatments and long-term gastrointestinal (GI) morbidity is scarce.
The authors report no conflict of interest.
Cite this article as: Wainstock T, Walfisch A, Shoham-Vardi I, et al. Fertility treatments and pediatric neoplasms of the offspring: results of a population-based cohort with a median follow-up of 10 years. Am J Obstet Gynecol 2017;216:314.e1-14.