American Journal of Obstetrics and Gynecology
Original ResearchGynecologyEffects of coffee consumption on gut recovery after surgery of gynecological cancer patients: a randomized controlled trial
Section snippets
Materials and Methods
This randomized controlled study was conducted at the Tepecik Education and Research Hospital, Department of Gynecological Oncology, Izmir, Turkey, between November 2013 and February 2016. Ethical approval was obtained from the Istanbul Kanuni Sultan Suleyman Education and Research Hospital Ethics Committee (reference number: 10/2013). Additionally, the study was registered with clinicaltrials.gov (no. NCT01990482).
Patients who had received a diagnosis of cervical, endometrial, or ovarian
Results
During the study period, in total, 118 patients were enrolled; 60 patients were assigned randomly to the coffee group, and 58 were assigned to the control group. Four patients (2 in the control group and 2 in the treatment group) were excluded after randomization because they no longer fulfilled the inclusion criteria. Ultimately, the conditions of 56 patients in the control group and 58 in the coffee group were analyzed. The reasons for exclusion before and after randomization are shown in the
Comment
This randomized trial showed that coffee consumption during the early postoperative period after abdominal hysterectomy and systematic PPL shortened the time to bowel motility and the ability to tolerate food. Moreover, a regression model showed that coffee consumption after surgery was independently protective against the development of POPI. It has a low cost, compared with pharmacologic management to prevent ileus (such as opioid receptor antagonists, ghrelin receptor agonists, and serotonin
Acknowledgments
We gratefully acknowledge the investigators, their coinvestigators and study coordinators, and the patients who participated in this trial.
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2021, Taiwanese Journal of Obstetrics and GynecologyCitation Excerpt :Exorphins are found in regular and decaffeinated coffee [10,11], and coffee stimulates motor activity in the colon by antagonizing adenosine receptors [12]. Güngördük et al. [13] conducted a randomized, controlled trial (RCT) of coffee consumption after laparotomy with hysterectomy and staging in 114 women with gynecologic malignancies. To date, this is the only investigation of the effectiveness of coffee consumption for the prevention of POI after gynecologic oncology surgery.
The authors report no conflict of interest.
Cite this article as: Güngördük K, Özdemir İA, Güngördük Ö, et al. Effects of coffee consumption on gut recovery after surgery of gynecological cancer patients: a randomized controlled trial. Am J Obstet Gynecol 2017;216:145.e1-7.