Original ArticleAnterior Segment Optical Coherence Tomography Angiography Imaging of Conjunctiva and Intrasclera in Treated Primary Open-Angle Glaucoma
Section snippets
Methods
This prospective, cross-sectional study was approved by the Institutional Review Board and Ethics Committee at Kyoto University Graduate School of Medicine, and was registered with the University Hospital Medical Information Network Clinical Trials Registry of Japan (UMIN: 000028853). All aspects of the study adhered to the tenets of the Declaration of Helsinki. After the study design and risks and benefits of participation were thoroughly explained, written informed consent was obtained from
Results
Twenty healthy subjects and 36 patients with glaucoma were initially enrolled. Two glaucomatous eyes were subsequently excluded because of poor-quality AS-OCTA images, leaving 20 healthy eyes and 34 eyes with glaucoma available for analysis. The demographics and clinical characteristics of the study subjects are summarized in Table 1. There was no significant difference in age, sex, axial length, or central corneal thickness between the healthy eyes and eyes with glaucoma (all P > .05). The
Discussion
The current study is the first report to investigate the conjunctival and intrascleral vasculature using AS-OCTA in eyes with glaucoma. There was a significant association between the superficial vessel density and use of prostaglandin eye drops. The deep vessel density decreased significantly with age in healthy eyes and increased with increasing IOP in treated eyes with glaucoma. Our findings indicate that AS-OCTA images might be useful for objective assessment of conjunctival hyperemia and
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