Original ArticleChoroidal Vascular Changes in Arteritic and Nonarteritic Anterior Ischemic Optic Neuropathy
Section snippets
Methods
This retrospective cross-sectional study included patients with acute A-AION and NA-AION visited at the Neuro-ophthalmology Service of our Institution (S.Orsola-Malpighi University Hospital, Bologna, Italy) during the period between January 1, 2015 and October 31, 2018. Inclusion criteria for both groups were age older than 60 years, sudden onset of unpainful monocular vision loss associated with optic disc edema and altitudinal and/or central visual field defects, and complete medical records
Results
Overall, 20 patients with A-AION, 20 patients with NA-AION, and 20 control subjects were included in the study. The demographic and clinical characteristics of patients and controls are reported in Table 1. There were no significant differences in sex distribution and IOP among the 3 groups (respectively, P = .410 and P = .492). Mean age was not significantly different in patients with A-AION and controls (P = .359), while patients with NA-AION were significantly younger than patients with
Discussion
The first crucial step in patients older than 60 years old presenting features of AION is to rule out GCA, given the potential for catastrophic bilateral loss of vision and systemic vasculitic sequelae. The immediate treatment of GCA with intensive high-dose corticosteroid may prevent visual loss but is not without risk. Therefore, the accuracy of the criteria used to establish or exclude the diagnosis is essential to minimize medication morbidities.22 However, the specificity of the currently
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2021, Survey of OphthalmologyCitation Excerpt :Hence, OCTA was superior to fluorescein angiography and ICGA while delineating finer vascular changes. Pellegrini and coworkers55 also showed that choroidal vasculature index in AION eyes was more severely affected as compared to normal/NAION eyes. To conclude, during acute phases of NAION with limited surface edema and clear visualization of CC, diffuse or localized patterned loss of CC can be expected.
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2020, Photodiagnosis and Photodynamic TherapyCitation Excerpt :In recent years, the use of binarization techniques on EDI-OCT images to evaluate choroidal changes with CVI measurements has enabled objective quantification of imaging results and has provided a chance for more detailed assessment of choroidal structures. Researchers have utilized these advances to enable accurate assessment of changes in the choroidal region by differentiating the vascular (luminal) and interstitial (stromal) region in various ocular diseases [8,9,12–15]. Kim et al. were the first to evaluate SFCT and CVI changes in 45 patients with HLA-B27-associated uveitis that presented with AAU attack [10].
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2020, Progress in Retinal and Eye ResearchCitation Excerpt :As such, investigators proposed the usage of CVI to assist physicians in identifying AION via OCT (Table 3G). Both A-AION and NA-AION had significantly lower CVI at the macula and peripapillary regions as compared to healthy controls (Pellegrini et al., 2019). The findings were in keeping with the pathogenesis of AION and were suggestive of choroidal ischemia due to reduced choroidal vascularity.
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