Original articleProton Beam Therapy Leads to Excellent Local Control Rates in Choroidal Melanoma in the Intermediate Fundus Zone
Section snippets
Patients and Data Collection
This is a retrospective single-center study of patients with choroidal malignant melanoma treated with proton beam radiotherapy in Berlin. The study was approved by the institutional review board of the Charité–Universitätsmedizin Berlin, Germany, and was in accordance with the Declaration of Helsinki specifications. This study focuses on tumors in the intermediate zone of the fundus not attaching the ciliary body. The minimal distance of the unifocal lesion to both the optic disc and fovea was
Results
Sixty-two patients met the inclusion criteria of our retrospective study. The mean age was 57.7 years (standard deviation [SD] 13.6 years). Twenty-nine patients were female, 33 were male. The overall range for tumor prominence was 1.7–12.6 mm (mean 7.6 mm, SD 2.9 mm), and it was 6.6–21.5 mm (mean 12.8 mm, SD 3.4 mm) for the largest tumor diameter. The respective fovea and disc distances ranged from 2.0 both to 10.1 mm and 11.3 mm with a mean distance of 4.6 mm to the fovea (SD 2.2 mm) and
Discussion
The management of patients with medium- and large-size uveal melanoma in the intermediate zone of the fundus is challenging. Proton beam brachytherapy for large tumors has been reported with or without additional surgical resection of the tumor tissue. However, a long-term follow-up of these patients was lacking so far. The intention of this study was to present the outcomes of all patients with choroidal melanomas in the intermediate fundus zone who met the inclusion criteria irrespective of
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