Original articleReproducibility of Retinal Thickness Measurements on Normal and Pathologic Eyes by Different Optical Coherence Tomography Instruments
Section snippets
Methods
This prospective study was performed on consecutive patients with pathologic retinal diseases and also normal retinas at the Eye Clinic, Department of Clinical Science, Luigi Sacco Hospital, University of Milan after obtaining informed written consent. All patients underwent OCT examination on the same clinic visit using 6 different OCT instruments: Stratus (Version 4.0.2; Carl Zeiss Meditec Inc), Cirrus (Version 2.0.0.54; Carl Zeiss Meditec Inc), Spectralis HRA+OCT (Version 3.1.4; Heidelberg
Results
Image analysis was performed on a total of 110 eyes (63 patients; 23 male, 40 female). The mean patient age was 65.7 (range: 20–90); the mean corrected visual acuity was 20/32 (range: 20/320–20/20). Thirty-one of the eyes (28.2%) were normal, 25 (22.7%) were affected by exudative age-related macular degeneration, 17 (15.5%) by epiretinal membrane without foveal contour alterations, 13 (11.8%) by cystoid macular edema from diabetic retinopathy, and 12 (10.9%) by nonexudative age-related macular
Discussion
In this study retinal thickness was evaluated and compared with 6 different OCT instruments on the same patients. This was done in order to attempt to simulate a standard clinical situation, not simply focusing on normal subjects or executing repetitive measurements to validate the reproducibility of that measurement.
The results suggest that the comparison between the instruments is nearly impossible, a conclusion shared by several authors looking at both normal and pathologic eyes.31, 32, 33,
Andrea Giani, MD, received his medical degree in 2003 from University of Milan, Italy, and completed his residency in 2007 at Eye Clinic, Luigi Sacco Hospital in Milan, Italy. He collaborated with IRCCS Bietti Foundation in Rome and Eye Clinic, Luigi Sacco Hospital in Milan as clinical investigator.
He joined the Massachusetts Eye and Ear Infirmary, Harvard Medical School in 2009, where he started a research fellowship. His specialty interests include age-related macular degeneration and retinal
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Andrea Giani, MD, received his medical degree in 2003 from University of Milan, Italy, and completed his residency in 2007 at Eye Clinic, Luigi Sacco Hospital in Milan, Italy. He collaborated with IRCCS Bietti Foundation in Rome and Eye Clinic, Luigi Sacco Hospital in Milan as clinical investigator.
He joined the Massachusetts Eye and Ear Infirmary, Harvard Medical School in 2009, where he started a research fellowship. His specialty interests include age-related macular degeneration and retinal degenerations. His clinical research interests are focused on the study of optical coherence tomography clinical applications and the evaluation of other imaging techniques, such as fundus autofluorescence. His basic research interests include the evaluation of age-related macular degeneration animal models and the assessment of new drugs efficacy in retinal degenerations.
He has published several peer-reviewed papers, he is author of numerous communication in international meetings, and he is co-author of a text on optical coherence tomography. He is a member of the Italian Association of Ophthalmology, and the Association for Research in Vision and Ophthalmology.