Brief report
Incidence of Intraoperative Floppy Iris Syndrome in Patients on Either Systemic or Topical α1-Adrenoceptor Antagonist

https://doi.org/10.1016/j.ajo.2006.07.046Get rights and content

Purpose

To evaluate the incidence of Intraoperative Floppy Iris syndrome (IFIS) in relation to the usage of α1-adrenoceptor antagonists.

Design

Prospective, interventional case series.

Methods

In 2,643 consecutive eyes of 1,968 patients undergoing cataract surgery, occurrence of IFIS and use of α1 antagonists were recorded.

Results

IFIS was observed in 29 eyes (1.1%) of 25 male patients, all of whom were receiving α1 antagonists. In those receiving systemic tamsulosin, α1A selective antagonist, IFIS developed in 25 (43.1%) of 58 eyes. In those receiving systemic naftopidil, α1A and α1D antagonists, IFIS was found in 4 (19.0%) of 21 eyes. There was no case of IFIS in patients who received other systemic α1 antagonists and in eyes treated with bunazosin eyedrops, a nonselective α1 antagonist.

Conclusions

IFIS occurred in 1.1% of cases treated with systemic α1A-adrenoceptor antagonists for benign prostatic hypertrophy. Topical nonselective α1 antagonist did not induce IFIS.

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Supported in part by Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology, Japan.

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