Clinical InvestigationAcute Ischemic Heart DiseaseImpact of renal dysfunction on 1-year mortality after acute myocardial infarction
Section snippets
Study design and population
We recorded in a prospective cohort all admissions of patients with MI over a 6-month period (from October 2000 to March 2001) in a specific geographic area: every patient with a confirmed diagnosis of acute MI, with or without ST-segment elevation according to the new definition of MI,16 in 1 of the 12 cardiology centers in the region of Franche-Comté (a region in Eastern France with a population of 1.2 million), was included. At the time of study design, no data were available in our region
Results
During the 6-month recruitment period, 754 patients were admitted with a final diagnosis of MI, 333 (44%) with STEMI and 421 (56%) with NSTEMI (no patient refused to be included). The median serum creatinine level was 12.6 mg/L (range 10.5-15.7 mg/L), and the median GFR was 48 mL/min/ per 1.73m2(range 35-65 mL/min/ per 1.73m2). The distribution of GFR in the whole population is displayed in Figure 1.
Discussion
In this study, a clear relationship was observed between 1-year mortality and GFR in patients admitted for acute MI. This relation remained significant when adjusted for the risk index at admission and the use of effective treatment.
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