Original ArticleLong-term follow-up after polypectomy treatment for adenoma-like dysplastic lesions in ulcerative colitis
Section snippets
Study group
The study group consisted of 34 UC patients, all of whom had at least one adenoma-like DALM detected during the course of endoscopic surveillance. These patients were the subjects of a previously published study by our research group.8 They originally were chosen by a retrospective search through the pathology files of the Brigham and Women’s Hospital and Beth Israel Deaconess Medical Center, Boston, MA, between 1990 and 1995. These patients were stratified into 2 subgroups for the purpose of
Clinical and pathologic characteristics
A summary of the clinical and pathologic features of the UC and control patients is presented in Table 1. Table 1 was reproduced from our previously published report that used the same cohort of UC patients and controls. Overall, the 34 UC patients and the 49 non-UC control patients showed a statistically similar distribution of polyps, mean polyp size, prevalence of high-grade dysplasia, and prevalence of a villous, or tubulovillous, growth pattern. Of the 34 UC patients, 12 (35%), 14 (41%),
Discussion
DALMs are a heterogeneous group of lesions that have varying endoscopic and morphologic features.5, 6 Recently, we proposed a clinically useful classification of DALMs into 2 broad groups (adenoma-like and non—adenoma-like), which is based on their gross (endoscopic) appearance.5 The main clinical difference between these 2 groups relates to their different risk for malignancy. It is well known that non—adenoma-like DALMs have up to an 80% risk for either metachronous or synchronous occurrence
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