Elsevier

Tuberculosis

Volume 88, Supplement 1, August 2008, Pages S75-S83
Tuberculosis

The early bactericidal activity of anti-tuberculosis drugs: a literature review

https://doi.org/10.1016/S1472-9792(08)70038-6Get rights and content

Summary

Quantification of mycobacteria in sputum from pulmonary tuberculosis patients has been used to evaluate patient's response to treatment since the earliest days of anti-tuberculosis chemotherapy. More recently the early bactericidal activity (EBA) of anti-tuberculosis agents, measured as the fall in viable colony forming units of Myco-bacterium tuberculosis in sputum early in therapy, has been shown to be an objective, repeatable measure of the ability of an agent to kill the metabolically active bacilli found in the sputum of patients with sputum microscopy smear-positive pulmonary tuberculosis. EBA offers an opportunity to rapidly demonstrate that a new agent has a detectable anti-tuberculosis effect in a relatively small number of patients, what the most appropriate dose is to take forward to more extensive clinical trials and allows the study of the relationship between pharmacokinetics and bactericidal activity and toxicity of the relevant agent.

References (49)

  • GL Hobby et al.

    Enumeration of tubercle bacilli in sputum of patients with pulmonary tuberculosis?

    Antimicrob Agents Chemother

    (1973)
  • A Jindani et al.

    The early bactericidal activity of drugs in patients with pulmonary tuberculosis?

    Am Rev Respir Dis

    (1980)
  • A Jindani et al.

    Bactericidal and sterilizing activities of antituberculosis drugs during the first 14 days?

    Am J Respir Crit Care Med

    (2003)
  • DA Mitchison et al.

    The measurement of early bactericidal activity?

    Balliéres Clin Infect Dis

    (1997)
  • N Kennedy et al.

    Early bactericidal and sterilizing activities of ciprofloxacin in pulmonary tuberculosis?

    Am Rev Respir Dis

    (1993)
  • FA Sirgel et al.

    The early bactericidal activity of rifabutin in patients with pulmonary tuberculosis measured by sputum viable counts: a new method of drug assessment?

    J Antimicrob Chemother

    (1993)
  • PR Donald et al.

    The early bactericidal activity of isoniazid related to its dose size in pulmonary tuberculosis?

    Am J Respir Crit Care Med

    (1997)
  • FA Sirgel et al.

    The early bactericidal activity of ciprofloxacin in patients with pulmonary tuberculosis?

    Am J Respir Crit Care Med

    (1997)
  • R Hafner et al.

    Early bactericidal activity of isoniazid in pulmonary tuberculosis. Optimization of methodology?

    Am J Respir Crit Care Med

    (1997)
  • HF Chambers et al.

    Activity of amoxicillin/clavulanate in patients with tuberculosis?

    Clin Infect Dis

    (1998)
  • FA Sirgel et al.

    A multicentre study of the early bactericidal activity of anti-tuberculosis drugs?

    J Antimicrob Chemother

    (2000)
  • R Dietze et al.

    Safety and bactericidal activity of rifalazil in patients with pulmonary The early bactericidal activity of anti-tuberculosis drugs: a literature review S83 tuberculosis?

    Antimicrob Agents Chemother

    (2001)
  • RD Gosling et al.

    The bactericidal activity of moxifloxacin in patients with pulmonary tuber-culosis?

    Am J Respir Crit Care Med

    (2003)
  • MWR Pletz et al.

    A, Roth A, Neuman K-H, Mauch H, Lode H. Early bactericidal activity of moxifloxacin in treatment of pulmonary tuberculosis: a prospective randomized study?

    Antimicrob Agents Chemother

    (2004)
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