Elsevier

Matrix

Volume 13, Issue 4, July 1993, Pages 297-306
Matrix

Type A Modules: Interacting Domains Found in Several Non-Fibrillar Collagens and in Other Extracellular Matrix Proteins

https://doi.org/10.1016/S0934-8832(11)80025-9Get rights and content

Abstract

A 200-amino acid long motif first recognized in von Willebrand Factor (type A module) has been found in components of the extracellular matrix, hemostasis, cellular adhesion, and immune defense mechanisms. At present the extracellular matrix is the predominant site of expression of type A modules since at least four non-fibrillar collagens and two non-collagenous proteins contain a variable number of modules ranging from one to twelve. The medules conform to a consensus motif made of short conserved subregions separated by stretches of variable length. The proteins that incorporate type A modules participate in numerous biological events such as cell adhesion, migration, homing, pattern formation, and signal transduction after interaction with a large array of ligands.

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