Atopic dermatitis: A genetic-epidemiologic study in a population-based twin sample
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Cited by (355)
Pediatric dermatology and common skin conditions
2023, Encyclopedia of Child and Adolescent Health, First EditionInterleukin 4 and Interleukin 4 receptor alpha gene variants and risk of atopy - A case control study based assessment
2021, Clinical ImmunologyCitation Excerpt :Nevertheless, the interplay of the genetic factors with environmental factors appears necessary for triggering of the disease. Concordance rates of up to 0.86 for identical twins and 0.5 for dizygotic twins confirm that the genetic predisposition plays a significant role in the development of AD [77,79,80]. Genome-wide linkage analysis had been used in different populations to date, and multiple candidate regions on multiple chromosomes had been associated with Atopy and interestingly, some candidate IL4 polymorphic regions are close to functional genes linked to the various phenotypes of Atopy [81–82] and hence inherited together indicating towards the co-existence of family history and respective IL4 SNP in an individual effected by atopic disorders.
Single nucleotide variations in genes associated with innate immunity are enriched in Japanese adult cases of face and neck type atopic dermatitis
2021, Journal of Dermatological ScienceWhat Have We Learned from GWAS for Atopic Dermatitis?
2021, Journal of Investigative DermatologyCitation Excerpt :Atopic dermatitis (AD) is a common (affecting 0.2–24.6% of children [Brown et al., 2008; Odhiambo et al., 2009] and up to 10% of adults [Bieber, 2008]) and complex trait caused by the interactions of multiple genetic and environmental factors. AD is highly heritable (72–86% concordance in monozygotic twin pairs [Larsen et al., 1986; Schultz Larsen, 1993]), and this provides the rationale for genetic studies. GWAS and GWAS meta-analysis have revealed ∼31 loci associated with AD, including four with secondary independent signals (Paternoster et al., 2015).
Atopic Dermatitis in Adults
2020, Medical Clinics of North AmericaResolving the etiology of atopic disorders by using genetic analysis of racial ancestry
2016, Journal of Allergy and Clinical Immunology
Supported by Danish Medical Research Council grant 12-0833, the fund of September 28 to F.S.L., and a research fellowship from the Danish Cancer Society to N.V.H.