Elsevier

Ophthalmology

Volume 87, Issue 7, July 1980, Pages 673-679
Ophthalmology

One-Year Observation of Transplanted Human Corneal Endothelium

https://doi.org/10.1016/S0161-6420(80)35188-9Get rights and content

Abstract

In 34 penetrating corneal transplants, endothelial photographs were taken preoperatively and at four postoperative intervals: four days, three weeks, three months, and one year. Preoperative corneas from older donors had larger and more variably sized endothelial cells. Although the mean endothelial cell loss at the four day examination was only 17%, it continued at a linear rate so that by one year almost half of the central endothelial cells were gone. The continued cell loss was not significantly affected by the operative cell loss, the presence of a lens postoperatively, or the recipient endothelial status. Six of the 34 transplants sustained documented episodes of allograft rejection, but their endothelial cell losses were minimized by prompt treatment with corticosteroids. The cell losses in the 20 phakic and 14 aphakic transplants were similar at both the four-day and one-year intervals, although the aphakic grafts were thicker at both times. Two additional transplants with vitreous touch to the graft endothelium sustained large continuing endothelial cell losses despite maintenance of clear, thin transplants.

References (17)

There are more references available in the full text version of this article.

Cited by (55)

  • Endothelial Keratoplasty: A Revolution in Evolution

    2012, Survey of Ophthalmology
    Citation Excerpt :

    A similar hyperopic shift has also been reported by Ham et al.43 The reported mean endothelial cell loss after PK ranges from 11–29% in the first 6 months,13,14,29 16–45% at 1 year,13,14,29,92 29–54% at 2 years,13,35,92 and 70% at 5 years.59 Six-month endothelial cell loss for DSEK ranges from 13–54%10,19,33,51,52,54,108,111,126,135,136 and endothelial cell loss at 1 year ranges from 15.6–61%.9,19,108,111,126,134,135

  • Descemet's Stripping Endothelial Keratoplasty: Safety and Outcomes. A Report by the American Academy of Ophthalmology

    2009, Ophthalmology
    Citation Excerpt :

    This demonstrates that DSEK is a relatively astigmatism-neutral surgery, as would be expected from the cataractlike incision. Table 4 describes the mean endothelial cell loss in published series of 11 eyes or more after both PK and DSEK.16,89,90,99,101,102,106,109,111–113,119–125 Mean percent endothelial cell loss in PK ranged from 11% to 29% at 2 to 6 months, 16% to 45% at 12 months, and 29% to 54% at 24 months.

  • Endothelial Cell Loss after Descemet Stripping with Endothelial Keratoplasty. Influencing Factors and 2-Year Trend

    2008, Ophthalmology
    Citation Excerpt :

    For example, 6-month ECD was correlated positively with donor ECD and was correlated inversely with donor age. Musch et al20 reported similar findings in a PK study with comparable statistical power. These results also are consistent with the findings of Nishimura et al12 that lower donor ECD and older donor age are risk factors for the development of late endothelial failure after PK.

  • Regrafting

    2008, Corneal Surgery: Theory Technique and Tissue: Fourth Edition
  • Graft Central Thickness Measurement by Rotating Scheimpflug Camera and Ultrasound Pachymetry after Penetrating Keratoplasty

    2007, Ophthalmology
    Citation Excerpt :

    Graft central thickness measurement is a useful method for following patients who have undergone penetrating keratoplasty. Graft central thickness decreases in the early postoperative months,23–26 then after the first postoperative year it increases progressively and significantly over time.27–30 After the first few postoperative weeks the graft central thickness has prognostic value: an increase in graft thickness above the upper normal limit for a specific postoperative time-point may be associated with an increased risk of graft failure or may indicate a graft complication.30

  • Outcome of graft central thickness after penetrating keratoplasty

    2005, Ophthalmology
    Citation Excerpt :

    In a study including 45 patients, Lindstrom et al11 reported an average graft thickness of 0.69 mm at 1 day after surgery, decreasing to 0.54 mm after 3 months. In a series of 34 grafts, Bourne12 reported a decrease in graft thickness from an average of 0.645 mm at 4 days to an average of 0.551 mm at 3 months. During the last 9 months of the first postoperative year, no significant modifications of graft thickness were observed in our patients.

View all citing articles on Scopus

Presented at the Eighty-Fourth Annual Meeting of the American Academy of Ophthalmology, San Francisco, November 5–9, 1979.

Supported by Research Grant EY-2037 from the National Eye Institute and by the Mayo Foundation.

View full text