Case Report“Stops walking when talking” as a predictor of falls in elderly people
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Cited by (764)
The content-dependent effect of the N-back task on dual-task performance
2023, Behavioural Brain ResearchImpaired task accuracy under dual-task conditions leads to issues such as falls and traffic accidents. Specific cognitive tasks (e.g., the N-back task) potentially improves dual-task performance. This study aims to establish an effective cognitive-task methodology for clinical practice and identify dual-task combinations in which the N-back task is likely to improve performance. Twenty-one young, healthy adults performed an intervention task (either N-back or control), followed by single- and dual tasks in the disappearing or dexterity condition, to assess its effect on different days. The participants performed force-control and calculation tasks in both disappearing and dexterity conditions. In the disappearing force-control task, target waveforms disappeared after a few practice trials, and the participants recalled them and adjusted their knee extension torque. The dexterity force-control task involved presenting complex waveforms. The participants carefully observed the waveforms, and adjusted their knee extension torque. We measured changes in the excitability of the dorsolateral prefrontal cortex (DLPFC) using near-infrared spectroscopy to determine whether the N-back-task-induced changes contributed to improving dual-task performance. For dual-task performance in the disappearing condition, the N-back task improved the performance of the disappearing force-control task, but the control task did not. The other results were the same regardless of the type of intervention task. The N-back task enhanced a portion of the DLPFC excitability. However, no correlation was observed between changes in dual-task performance and in DLPFC excitability. Our findings may contribute to establishing an effective method for improving dual-task performance using cognitive tasks.
Functional near-infrared spectroscopy (fNIRS) is a method to measure cerebral hemodynamics. Determining the changes in prefrontal cortex (PFC) hemodynamics during dual-task paradigms is essential in explaining alterations in physical activities, especially in older adults.
To systematically review and meta-analyze the effects of dual-task paradigms on PFC hemodynamics in older adults.
The search was conducted in PubMed, Scopus, and Web of Science from inception until March 2023 to identify studies on the effects of dual-task paradigms on PFC hemodynamics. The meta-analysis included variables of cerebral hemodynamics, such as oxygenated hemoglobin (HbO2) and deoxygenated hemoglobin (HbR). The heterogeneity of the included studies was determined using the I2 statistic. Additionally, subgroup analysis was conducted to compare the effects of different types of cognitive tasks.
A total of 37 studies were included in the systematic review, 25 studies comprising 2224 older adults were included in the meta-analysis. Our findings showed that inhibitory control and working memory tasks significantly increased HbO2 in the PFC by 0.53 (p < 0.01, 95% CI = 0.37 to 0.70) and 0.13 (p < 0.01, 95% CI = 0.08 to 0.18) μmol/L, respectively. Overall, HbO2 was significantly increased during dual-task paradigms by 0.36 μmol/L (P < 0.01, 95% CI = 0.27 to 0.45). Moreover, dual-task paradigms also decreased HbR in the PFC by 0.04 (P < 0.01, 95% CI = −0.07 to −0.01). Specifically, HbR decreased by 0.08 during inhibitory control tasks (p < 0.01, 95% CI = −0.13 to −0.02), but did not change during working memory tasks.
Cognitive tasks related to inhibitory control required greater cognitive demands, indicating higher pfc activation during dual-task paradigms in older adults. for clinical implications, the increase in pfc oxygenated hemoglobin and decrease in pfc deoxygenated hemoglobin may help explain why older adults are more likely to fall during daily activities.
Combining walking with a demanding cognitive task is traditionally expected to elicit decrements in gait and/or cognitive task performance. However, it was recently shown that, in a cohort of young adults, most participants improved performance when walking was added to performance of a Go/NoGo response inhibition task. The present study aims to extend these previous findings to an older adult cohort, to investigate whether this improvement when dual-tasking is observed in healthy older adults. Mobile Brain/Body Imaging (MoBI) was used to record electroencephalographic (EEG) activity, three-dimensional (3D) gait kinematics and behavioral responses in the Go/NoGo task, during sitting or walking on a treadmill, in 34 young adults and 37 older adults. Increased response accuracy during walking, independent of age, was found to correlate with slower responses to stimuli (r = 0.44) and with walking-related EEG amplitude modulations over frontocentral regions (r = 0.47) during the sensory gating (N1) and conflict monitoring (N2) stages of inhibition, and over left-lateralized prefrontal regions (r = 0.47) during the stage of inhibitory control implementation (P3). These neural activity changes are related to the cognitive component of inhibition, and they were interpreted as signatures of behavioral improvement during walking. On the other hand, aging, independent of response accuracy during walking, was found to correlate with slower treadmill walking speeds (r = -0.68) and attenuation in walking-related EEG amplitude modulations over left-dominant frontal (r = -0.44) and parietooccipital regions (r = 0.48) during the N2 stage, and over centroparietal regions (r = 0.48) during the P3 stage. These neural activity changes are related to the motor component of inhibition, and they were interpreted as signatures of aging. Older adults whose response accuracy ‘paradoxically’ improved during walking manifested neural signatures of both behavioral improvement and aging, suggesting that their flexibility in reallocating neural resources while walking might be maintained for the cognitive but not for the motor inhibitory component. These distinct neural signatures of aging and behavior can potentially be used to identify ‘super-agers’, or individuals at risk for cognitive decline due to aging or neurodegenerative disease.
Influences of different cognitive loads on central common neural drives to the ankle muscles during dual-task walking
2023, Neuroscience LettersWhile dual-task walking with additional cognitive tasks may decrease walking performance, many studies have also shown increases in walking performance during dual tasks, especially as cognitive load increases. However, the neural mechanisms that cause changes in postural control during dual tasks according to the difference in cognitive load remain unclear. Therefore, this study aimed to investigate the influence of different cognitive loads on the neural control of muscle activity during dual-task walking using intra- and intermuscular coherence analyses. Eighteen healthy young adults were subjected to treadmill walking measurements in a single-task condition (normal walking without cognitive load) and two dual-task conditions (watching digits and digit 2-back task) with the measurements of reaction time to auditory stimulation. During walking with the digit 2-back task, stride-time variability was significantly reduced compared to that during normal walking, and reaction time was significantly delayed compared to those during normal walking and walking with watching digits. The peak value of the tibialis anterior intramuscular coherence in the beta band (15–35 Hz) significantly increased during walking with the digit 2-back task than that during walking with watching digits. The present results suggest that young adults can increase their central common neural drive and decrease their walking variability for concentration on cognitive tasks during dual-task walking.
How Reliable and Valid are Dual-Task Cost Metrics? A Meta-analysis of Locomotor-Cognitive Dual-Task Paradigms
2023, Archives of Physical Medicine and RehabilitationTo assess the retest reliability, predictive validity, and concurrent validity of locomotor and cognitive dual-task cost (DTC) metrics derived from locomotor-cognitive dual-task paradigms.
A literature search of electronic databases (PubMed, PsycINFO, MEDLINE, CINAHL, and Scopus) was conducted on May 29th, 2021, without time restriction.
For 1559 search results, titles and abstracts were screened by a single reviewer and full text of potentially eligible papers was considered by 2 independent reviewers. 25 studies that evaluated retest reliability, predictive validity, and concurrent validity of locomotor-cognitive DTC in healthy and clinical groups met inclusion criteria.
Study quality was assessed using the Consensus-Based Standards for the Selection of Health Measurement Instrument checklist. Data relating to the retest reliability, predictive validity, and concurrent validity of DTC were extracted.
Meta-analysis showed that locomotor DTC metrics (intraclass correlation coefficient [ICC]=0.61, 95% confidence interval [CI; 0.53.0.70]) had better retest reliability than cognitive DTC metrics (ICC=0.27, 95% CI [0.17.0.36]). Larger retest reliability estimates were found for temporal gait outcomes (ICC=0.67-0.72) compared with spatial (ICC=0.34-0.53). Motor DTC metrics showed weak predictive validity for the incidence of future falls (r=0.14, 95% CI [-0.03.0.31]). Motor DTC metrics had weak concurrent validity with other clinical and performance assessments (r=0.11, 95% CI [0.07.0.16]), as did cognitive DTC metrics (r=0.19, 95% CI [0.08.0.30]).
Gait-related temporal DTC metrics achieve adequate retest reliability, while predictive and concurrent validity of DTC needs to be improved before being used widely in clinical practice and other applied settings. Future research should ensure the reliability and validity of DTC outcomes before being used to assess dual-task interference.
Validity and reliability of a ruler drop test to measure dual-task reaction time, choice reaction time and discrimination reaction time
2024, Aging Clinical and Experimental Research