Slower heterosexual spread of HIV-2 than HIV-1

doi:10.1016/S0140-6736(94)90065-5

The Lancet

Volume 343, Issue 8903, 16 April 1994, Pages 943-946

https://doi.org/10.1016/S0140-6736(94)90065-5 Get rights and content

Abstract

Because of the similar virological properties of HIV types 1 and 2, HIV-2 was assumed to be as infectious and capable of inducing AIDS as HIV-1. Seroepidemiological studies have shown significant rates of HIV-2 infection in West Africa, and surveys from other regions of the world indicate that the spread of HIV-2 infection continues. However the pathogenic potential of HIV-2 is considered to be lower than that of HIV-1. It is therefore important to understand the transmission properties of HIV-2 and its contribution to the AIDS pandemic. Since 1985,we have prospectively studied 1452 registered female prostitutes in Dakar, Senegal, with sequential evaluation of their antibody status to HIV-1 and HIV-2. During the study the overall incidence of HIV-1 and HIV-2 was the same (1·11 per 100 person-years of observation [pyo]). However, the annual incidence of HIV-1 increased substantially: there was a 1·4-fold increased risk per year and thus a 12-fold increase in risk over the entire study period. The incidence of HIV-2 remained stable, despite higher HIV-2 prevalence. In our population the heterosexual spread of HIV-2 is significantly slower than that of HIV-1, which strongly suggests differences in the viruses' infectivity potential.

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Slower heterosexual spread of HIV-2 than HIV-1

Abstract

HIV-2 link to AIDS in West Africa

J Acq Immune Defic Syndr

Human immunodeficiency virus type 2 infection associated with AIDS in West Africa

N Engl J Med

Clinical, hematologic, and immunologic cross-sectional evaluation of individuals exposed to human immunodeficiency virus type 2 (HIV-2)

AIDS Res Hum Retroviruses

Mathematical and statistical studies of the epidemiology of HIV

AIDS

Epidemiological parameters of HIV transmission

Nature

Prevalence and risk determinants of human immunodeficiency virus type 2 (HIV-2) and human immunodeficiency virus type 1 (HIV-1) in West African female prostitutes

Am J Epidemiol

Proposed WHO criteria for interpretation results from Western blot assays for HIV-1, HIV-2, and HTLV-I/ HTLV-II

Wkly Epidemiol Rec