CORRECTION OF ABNORMAL COAGULATION IN CHRONIC LIVER DISEASE BY COMBINED USE OF FRESH-FROZEN PLASMA AND PROTHROMBIN COMPLEX CONCENTRATES
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2012, Journal of HepatologyCitation Excerpt :The thrombopoietin analog eltrombopag may be thrombogenic at least in stable cirrhosis (there has been a suspended trial in this area), probably because of the interaction with the very high levels of vWF in cirrhosis. The use of fresh frozen plasma is limited by the volume of transfusions; safer prothrombin complex concentrates which have 20 times the concentration of factors than FFP are now available [129]. Currently, prophylactic transfusions of any coagulation products are difficult to justify and it is likely that more comprehensive, global tests of coagulation are needed to guide the correction of coagulation on an individual basis [130].
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