Preliminary CommunicationsTHE MECHANISM OF THE ACIDOSIS CAUSED BY INFUSION OF SALINE SOLUTION
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Acid-Base Assessment: When and how to apply the henderson-hasselbalch equation and strong ion difference theory
2014, Veterinary Clinics of North America - Food Animal PracticeCitation Excerpt :The strong ion approach leads directly to the conclusion that the rapid intravenous administration of equal volumes of 0.9% NaCl, Ringer solution, sodium gluconate, 5% dextrose, and mannitol produce the same acidifying effect because the SID of all 5 solutions equals 0 mEq/L (see Fig. 4).45 Current application of SID theory, therefore, explains why a similar decrease in pH occurs in dogs administered 0.9% NaCl, 5% dextrose, or 5% mannitol intravenously at 88 mL/kg body weight.39 Fig. 4 also provides an explanation as to why the rapid intravenous administration of large volumes (70 mL/kg) of 0.9% NaCl produces a metabolic acidosis in humans, whereas administration of equivalent volumes of lactated Ringer solution does not cause a detectable change in plasma pH.47
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