Elsevier

The Lancet

Volume 352, Issue 9133, 26 September 1998, Page 1034
The Lancet

Research Letters
Thyrotoxicosis incidence in Switzerland and benefit of improved iodine supply

https://doi.org/10.1016/S0140-6736(05)60076-1Get rights and content

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    The increase in incidence hyperthyroidism after a properly monitored introduction of iodine into populations with mild-to-moderate iodine deficiency is transient because the resulting iodine sufficiency in the population reduces the future risk for the development of autonomous thyroid nodules. In Switzerland in 1980, iodine content of salt was raised from 7·5 to 15 ppm to correct mild iodine deficiency, and the median UIC increased from roughly 80 to 150 μg per g of creatinine.49 During the first 2 years after this increase, the incidence of toxic nodular goitre rose by 12%, but regressed over the next 4 years to a stable concentration of only 25% of the initial incidence.49

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    This condition is transient and correlated to the level of iodine deficiency and the amount of iodine administered. In 1980 in Switzerland, the iodine content in salt was increased from 7.5 to 15 mg/kg, doubling iodine intake; incidence of toxic nodular goitre increased by 12% in the first 2 years after the increase, but then declined to a level of only 25% of the initial incidence [73,74]. In Denmark, starting from June 1998, a programme of voluntary use of iodized salt was launched by the Danish Food and Veterinary Administration in cooperation with salt manufactures and the food industry.

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