Clinical significance of occult micrometastasis in lymph nodes from patients with early gastric cancer who died of recurrence1
References (24)
- et al.
The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells
Cell
(1982) - et al.
Prognostic significance of micrometastatic tumour cells in bone marrow of colorectal cancer patients
Lancet
(1992) - et al.
Cytokeratin staining reveals micrometastasis in lymph nodes of early gastric cancer
Surgery
(1995) - et al.
Predictors of lymph node metastasis in early gastric cancer
Br J Surg
(1992) - et al.
Lymphadenectomy for cure in patients with early gastric cancer and lymph node metastasis
Am J Surg
(1988) - et al.
Effect of lymph node dissection on the prognosis in patients with node-negative early gastric cancer
Surgery
(1995) - et al.
Prophylactic lymph node dissection in patients with advanced gastric cancer promotes increased survival time
Cancer
(1992) - et al.
Early carcinoma of the stomach
Surg Gynecol Obstet
(1993) - et al.
Gastric cancer in patients over 70 years of age
Br J Surg
(1995) - et al.
DNA ploidy is closely linked to tumor invasion, lymph node metastasis, and prognosis in clinical gastric cancer
Cancer
(1988)
Growth pattern and p53 overexpression in patients with early gastric cancer
Cancer
Restaging of colorectal cancer based on the identification of lymph node micrometastases through immunoperoxidase staining of CEA and cytokeratins
Dis Colon Rectum
Cited by (232)
Lymph node micrometastasis of poorly differentiated node-negative gastric cancer risks a worse-than-expected survival outcome under standard management algorithm
2022, European Journal of Surgical OncologyDetection and prognostic significance of isolated tumor cells and micrometastases in pelvic lymph nodes of patients with early ovarian clear cell carcinoma
2021, Journal of the Formosan Medical AssociationA better prognostic stratification for the 8th edition of the AJCC staging system of gastric cancer by incorporating pT4aN0M0 into stage IIIA
2019, Surgical OncologyCitation Excerpt :The 3-year recurrence-free survival rate of the patients considered to be positive for cancer cells exposed to the serosa of the primary gastric tumor by their method (41.7%) was significantly (log rank P = 0.0002) worse than that of the patients with negative results (81.0%). Several investigators reported that a conventional pN0 diagnosis after radical surgery for gastric cancer was not a guarantee against recurrence because of lymph node micrometastasis [25–27]. A study from Korea indicated that lymph node micrometastasis is clinically significant as a risk factor for recurrent gastric cancer, where 62.2% of the cases had lymph node micrometastasis in 164 cases diagnosed with pT4aN0M0 by immunohistochemical staining with an anti-cytokeratin antibody.
Practical intraoperative pathologic evaluation of sentinel lymph nodes during sentinel node navigation surgery in gastric cancer patients - Proposal of the pathologic protocol for the upcoming SENORITA trial
2016, Surgical OncologyCitation Excerpt :Most studies regarding the clinical significance of occult metastasis in gastric cancer patients are retrospective studies of cases of conventional gastrectomy and lymph node dissection, and the oncologic outcome is controversial [32]. Since the potential candidates for SNNS in the forthcoming phase III clinical trial would be patients with cT1N0 gastric cancer, studies that exclusively included patients with EGC were reviewed here to investigate the prognostic significance of occult metastasis in patients diagnosed with EGC without histologic lymph node metastasis by conventional HE staining (Table 2) [33–38]. The incidence of occult metastasis in these studies ranged 10.0–24.6% by additional IHC, which indicates that even in patients with EGC, the occult metastasis rate reached 10% or more.
TUMOR MARKERS EXPRESSION LEVELS IN GASTRIC CANCER PATIENT’S PERIPHERAL BLOOD BY RT-PCR ASSESSMENT
2023, Arquivos Brasileiros de Cirurgia Digestiva
- 1
Supported by grant-in-aid for scientific research (C) (06671286) from the Ministry of Education, Science and Culture in Japan.