Original articleMedication misuse, abuse and dependence in chronic pain patients
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Reprint of: Efficacy, tolerability, and safety of non-pharmacological therapies for chronic pain: An umbrella review on various CAM approaches
2018, Progress in Neuro-Psychopharmacology and Biological PsychiatryCitation Excerpt :Indeed, long-term administration of non-steroidal anti-inflammatory drugs have been linked to numerous complications, such as stomach ulcers, liver failure, and cardiovascular toxicity (Ong et al., 2007). Similarly, opioids have been associated with many adverse effects, like nausea, constipation, and present a serious risk of dependency for patients with a history of substance abuse (Kouyanou et al., 1997; Moore and McQuay, 2005; Porter and Jick, 1980). Although treatment of psychiatric co-morbidity such as anxiety and depression is common to improve management of chronic pain, benzodiazepines and tricyclic antidepressants have been linked to greater pain severity and lower feelings of self-efficacy (Nielsen et al., 2015; Raja et al., 2002).
Substance-related disorders: A review of prevalence and correlates among patients with chronic pain
2018, Progress in Neuro-Psychopharmacology and Biological PsychiatryEfficacy, tolerability, and safety of non-pharmacological therapies for chronic pain: An umbrella review on various CAM approaches
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