Alimentary TractCrohn's disease in Olmsted County, Minnesota, 1940–1993: Incidence, prevalence, and survival☆,☆☆
Section snippets
Setting
Olmsted County, situated in southeastern Minnesota, comprised approximately 106,000 people in the 1990 U.S. Census. The county's urban center, Rochester, comprised approximately 71,000 people in 1990. The remainder of the county is rural. In 1990, 96% of the population was white. Although 25% of the residents are employed in health care services (vs. 8% nationwide) and the level of education is higher (30% have completed college vs. 21% nationwide), the residents of Olmsted County are
Demographic characteristics
Between 1940 and 1993, a new diagnosis of Crohn's disease was made in 225 Olmsted County residents. One hundred twenty-two patients were female (54%), resulting in a female to male ratio of 1.2:1. The mean age at diagnosis was 33.4 years. The median age at diagnosis was 29.5 years (range, 4.2–83.8 years). The diagnosis was most commonly made in the third and fourth decades of life (Figure 1). There was no
Discussion
The incidence of Crohn's disease in Olmsted County, Minnesota, increased dramatically during the 1960s and early 1970s, and has since stabilized at a rate of roughly 7 cases per 100,000 person-years. The prevalence rate increased by 46% between 1980 and 1991. The “classic” age distribution of onset of Crohn's disease, with the majority of cases diagnosed in the third and fourth decades of life, did not become evident in our county until the mid-1960s. The overall survival of this inception
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Supported by Schering–Plough, by National Institute of Arthritis and Musculoskeletal and Skin Diseases grant AR30582, and by the Mayo Foundation for Medical Education and Research.
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Address requests for reprints to: Edward V. Loftus, Jr., M.D., Division of Gastroenterology, Mayo Clinic, 200 First Street, Southwest, Rochester, Minnesota 55905. e-mail: [email protected]; fax: (507) 266-0335.