Chest
Clinical InvestigationsDIFFUSE DISEASESImpact of Angiotensin-Converting Enzyme Inhibitors and Statins on Survival in Idiopathic Pulmonary Fibrosis
Section snippets
Materials and Methods
The Mayo Institution Review Board approved this study. Systematic search of the computerized patient database of our institution revealed 487 patients who satisfied diagnostic criteria for IPF seen at Mayo Clinic Rochester during the period of January 1, 1994, to December 31, 1996. The clinical, radiologic, and histopathologic diagnostic criteria used to establish cases of IPF have been previously described.19 Briefly, IPF was diagnosed if the patients presented with compatible clinical
Demographics
During the 3-year period under study, IPF was diagnosed in 487 patients. Eight international (non-US/non-Canadian) persons were excluded from analysis because follow-up data could not be obtained, and one subject was excluded because on chart review for ACEI and statin use the patient was found to have had IPF incorrectly diagnosed previously. Baseline characteristics for the 478 patients analyzed for this study are summarized in Table 1. The most common recommended treatment for IPF was
Discussion
The attention in IPF/UIP pathogenesis has shifted from chronic inflammation to aberrant wound/repair mechanisms with increased emphasis on the interplay of fibroblasts and alveolar epithelial cells. Consequently, the search for therapies has turned from traditional anti-inflammatory agents to those that may modify the cellular and cytokine constituents of fibroproliferative processes, as exemplified by the clinical trials involving pirfenidone23 and interferon γ.24 However, results have been
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Cited by (77)
Statins’ still controversial role in pulmonary fibrosis: What does the evidence show?
2022, Pulmonary Pharmacology and TherapeuticsCitation Excerpt :A summary of the above-described published data is presented in Table 2. Despite past reports implicating statins in the development of ILDs, recent studies have shown that statins might confer a survival benefit in various forms of ILDs including IPF [8–10,44]. Discrepancies might be attributed to issues pertaining to methodology; nonetheless, they highlight the need for meticulous and high-quality prospective research.
The effect of statin therapy on disease-related outcomes in idiopathic pulmonary fibrosis: A systematic review and meta-analysis
2021, Respiratory Medicine and ResearchTherapeutic pro-fibrogenic signaling pathways in fibroblasts
2017, Advanced Drug Delivery ReviewsCitation Excerpt :Targeting RAS system has been shown to affect also experimental lung fibrosis with Ang II exerting profibrotic action on lung fibroblasts, leading to growth factor expression, ECM synthesis and migration mediated through both AT1 and AT2 receptors, with several studies suggesting a protective role for strategies leading to ACE inhibition (reviewed in ref. [342]). However, retrospective analysis of clinical use of ACE inhibitors and/or statins indicated no significant change in survival in IPF patients [343]. Oxidative stress can be defined as an imbalance between an excessive generation of ROS and the capacity of the cells and/or tissues to eliminate, inactivate or scavenge them [167–170].
Statin use and virus-related cirrhosis: A systemic review and meta-analysis
2017, Clinics and Research in Hepatology and Gastroenterology
Funding was provided by Mayo institutional funds.