Original Articles: CardiovascularS100β after coronary artery surgery: release pattern, source of contamination, and relation to neuropsychological outcome
Section snippets
Study design
The study comprised 132 patients who underwent operation at the Division of Cardiac Surgery, University Hospital MAS, Malmoe, Sweden, during a period of 22 months. Included were patients planned for elective CABG with CPB as their sole procedure. The study protocol was approved by the local ethics committee. Patients with a history of stroke, transient ischemic attack (TIA), reversible neurological disorder (RIND), known carotid artery disease, or other brain diseases were excluded. To avoid
Results
The demographics for the three groups are shown in Table 1
Comment
In this study, an extracerebral source for S100β release to blood during and after cardiac operations is established. This finding offers a plausible explanation of why earlier studies on S100β and cardiac surgery have found correlations between adverse neurological outcome and elevated S100β levels only at 7 hours after CPB or later (Sandström E, Svenmarker S, Karlsson K, Åberg T. S-100 and memory function after cardiac surgery. European Association of Cardiothoracic Surgery meeting, Prague,
Acknowledgements
We thank Peter Höglund, MD, PhD, Department of Clinical Pharmacology, Lund University Hospital, Sweden for his valuable advice on kinetic models. We also express our gratitude to Kjell Pennert, Chief Statistician, Clinical Data Care, Lund, Sweden, for taking time to review the statistics used in our kinetic model.
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