Original ArticlesPorous-Type Tracheal Prosthesis Sealed With Collagen Sponge
Section snippets
Collagen Solution
Collagen was extracted from pig skin and treated with a method similar to that described in our previous study [5]. It was supplied by Nippon Meat Packers Inc, Ibaraki, Japan. This purified collagen, which consisted of type I collagen (70% to 80%) and type III collagen, was dissolved in hydrochloric acid solution with a pH of 3.0, so that its concentration became 1.3%.
Prosthesis
The bulk structure of the prosthesis was the same as we used in the previous study 5, 6. It consisted of a fine Marlex mesh (CR
Results
Neither operative death nor dehiscence of the tracheal prosthesis occurred in any animal. Two dogs died within 3 months of tracheal reconstruction. One died of an anesthetic accident during bronchoscopic examination at 6 weeks, and the other of suffocation by sputum at 10 weeks. Eight dogs were killed between 6 and 24 months; 3 dogs at 6 months, 4 at 12 months, and 1 at 24 months (Table 1).
Comment
Reconstruction of circumferential tracheal defects is performed after tissue extirpation in cancer or resection of stenotic regions, and an end-to-end anastomosis is now considered to be the method of choice for defects of up to approximately 6 cm in adults 7, 8, 9. However, in the case of larger defects, another method of reconstruction is required. Researchers encouraged by the success of artificial vascular grafts have developed a variety of tracheal prostheses using synthetic biomaterials.
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