Relation of levels of hemostatic factors and inflammatory markers to the ankle brachial index☆
Section snippets
Participant identification
This study was performed in patients participating in the Walking and Leg Circulation Study, an observational study assessing the natural history of lower extremity functioning in patients with and without PAD.9, 10 The study was approved by the institutional review board of Northwestern University’s Feinberg School of Medicine and Catholic Health Partners Hospital. All participants gave informed consent. Participants were ≥55 years old.
PAD was defined as ABI <0.90. Absence of PAD was defined
Results
Of 2,662 potential participants identified from the noninvasive vascular laboratories, 220 were deceased, 464 could not be located, 375 were ineligible, and 597 agreed to participate. Of 467 potential participants identified from the general medicine practice, 7 were deceased, 63 could not be located, 22 were ineligible, and 143 participated. Of 740 patients enrolled, 601 (81.2%) had sufficient blood drawn for testing of all blood factor levels and are included in these analyses.
Table 1 lists
Discussion
Our results show that d-dimer levels are significantly associated with the extent of lower extremity arterial obstruction as measured by the ABI. Of the blood factors studied, d-dimer was associated significantly and independently with the ABI among patients with cardiac or cerebrovascular disease and among patients without cardiac or cerebrovascular disease, adjusting for CRP, fibrinogen, SAA, t-PA/PAI-1 ratio, prothrombin 1.2, total cholesterol, high-density lipoprotein, and other known and
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Low ankle brachial index predicts poor outcomes including target lesion revascularization during the long-term follow up after drug-eluting stent implantation for coronary artery disease
2020, Journal of CardiologyCitation Excerpt :Presence of PAD is a marker of systemic atherosclerosis that stems from vascular endothelial dysfunction. CAD patients with PAD have higher circulating levels of inflammatory and prothrombotic biomarkers [21,22]. In addition, other reports have shown that some markers of oxidative stress were associated with PAD [23,24].
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This study was supported by grants #R01-HL58099 and R01-HL64739 from the National Heart Lung and Blood Institute, Bethesda, Maryland, and by grant #RR-00048 from the National Center for Research Resources, National Institutes of Health, Bethesda, Maryland. Dr. McDermott is a recipient of an Established Investigator Award from the American Heart Association, Dallas, Texas.