Ventricular dysfunction and necrosis produced by adrenochrome metabolite of epinephrine: Relation to pathogenesis of catecholamine cardiomyopathy*
References (63)
- et al.
Isoproterenol-induced acute experimental cardiac necrosis in the turtle
Am Heart J
(1968) - et al.
Studies in cardiac necrosis. I. Production of cardiac lesions with sympathomimetic amines
Toxicol Appl Pharmacol
(1965) - et al.
Studies in cardiac necrosis. II. Cardiovascular effects of sympathomimetic amines producing cardiac lesions
Toxicol Appl Pharmacol
(1965) - et al.
Induction of necrosis and failure in the isolated perfused rat heart with oxidized isoproterenol
J Mol Cell Cardiol
(1975) - et al.
Functional and subcellular changes in the isolated rat heart perfused with oxidized isoproterenol
J Mol Cell Cardiol
(1978) - et al.
A possible role of noradrenaline in the development of myocardial infarction. An experimental study in the isolated rat hearts
Am Heart J
(1978) - et al.
A histochemical and electron microscopic study of epinephrine-induced myocardial necrosis
J Mol Cell Cardiol
(1970) - et al.
Glutathione and eythylene-diamine-tetracetate antagonism of uncoupling of oxidative phosphorylation
Biochim Biophys Acta
(1956) - et al.
Adrenochrome inhibition of oxidative phosphorylation by rat brain mitochondria
Biochem Pharmacol
(1964) Tissue respiration and substrate utilization of heart muscle slices
Fukuoka Igaku Zasshi
(1958)Chem Abstracts
(1959)
Myocardial fiber necrosis due to intracellular Ca-overload. A new principle in cardiac pathophysiology
Die Autokatalyse der Adrenalinoxydation
Biochem Z
Alterations in adrenochrome induced myocardial cell damage and contractile failure by cations
Experimental myocarditis; a study of the histological changes following intravenous injections of adrenalin
J Exp Med
1-norepinephrine myocarditis
Am J Clin Pathol
An infarct-like myocardial lesion and other toxic manifestations produced by isoproterenol in the rat
Arch Pathol
Aspect microcirculatoire des lesions myocardiques provoquees par l'infusion de catecholamines. Etude ultrastructural a l'aide de traceurs de diffusion. I. Isoproterenol
Pathol Biol (Paris)
Aspect microcirculatoire des lesions myocardiques provoquees par l'infusion de catecholamines. Etude ultrastructural a l'aide de traceurs de diffusion. II. Norepinephrine
Pathol Biol (Paris)
Isoproterenol-induced myocardial infarction in animals
Arch Pathol
Myocardial infarction and necrotizing arteritis in hamsters, produced by isoproterenol (Isoprel)
Med Serv J Can
Pathogenesis of isoproterenol induced myocardial alterations: Functional and morphological correlates
Studies on infarct-like myocardial necrosis produced by isoproterenol: A review
Rev Can Biol
Fine structural study of myocardial changes induced by isoproterenol in Rhesus monkeys (macaca mulatta)
Am J Pathol
Myocardial ion and lipid exchange during ischemia and catecholamine induced necrosis: Relation to regional blood flow
Pathogenic significance of adrenalin and related substances in heart muscle
Exp Med Surg
Effect of catecholamines and adrenergic blocking agents on oxidative phosphorylation in rat heart mitochondria
Circ Res
Direct toxic effects of isoproterenol on cultured cardiac muscle cells
Experientia
Myocardial lesions induced by natural catecholamines in vitro
Europ J Cardiol
Myocytolysis and mitochondrial calcification in rat myocardium after low doses of isoproterenol
Am J Pathol
Early alterations of cardiac muscle cells in isoproterenol induced necrosis
Arch Pathol
Electron microscopic studies on isoproterenol-induced myocardial lesions in rats
Jpn Heart J
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Chlorogenic acid ameliorates isoproterenol-induced myocardial injury in rats by stabilizing mitochondrial and lysosomal enzymes
2017, Biomedicine and PharmacotherapyCitation Excerpt :The QT interval prolongation related with cardiac vagal dysfunction represents cardiac toxic potential such as indication of arrhythmias, cardiac dysfunction and sudden cardiac collapse [51]. These changes might be due to the consecutive loss of myocardial cell membrane integrity which is consistent with the earlier reports [52,53]. CGA pretreatment brought back all the above parameters to near normalcy in ISO induced rats which might be due to the antioxidant and the cell membrane protective effect of CGA and this protection is associated with reduced oxidative stress properties of CGA [15].
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This study was supported by grants from The Great West Life Assurance Company, Winnipeg.