Original investigationA physical chemical approach to the analysis of acid-base balance in the clinical setting
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2018, Journal of Surgical ResearchCitation Excerpt :Thus, the SBE can be normal in the presence of complex metabolic acid–base disorders, as observed in several clinical studies.5,57,61,79,89-92 Partitioning the SBE into its three physical–chemical contributors with the Fencl-Stewart approach allows for a better qualitative description of metabolic acid–base disorders.73 Conditions like hypochloremia in the setting of a SIG acidosis or hyperchloremia in the context of hypoalbuminemia might actually not represent complex metabolic acid–base disorders per se, but just physiological compensatory mechanisms.72
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Copyright © 1993 Published by Elsevier Inc.