General Pharmacology: The Vascular System
General paperChronic administration of aqueous extract of Stevia rebaudiana (Bert.) Bertoni in rats: Endocrine effects
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Cited by (40)
Toxicological evaluation of ethanolic extract from Stevia rebaudiana Bertoni leaves: Genotoxicity and subchronic oral toxicity
2017, Regulatory Toxicology and PharmacologyCitation Excerpt :No difference between groups was found regarding these pathological changes. The anti-fertility effect of aqueous extraction of Stevia, which mainly contains stevioside and rebaudioside A (the sweetener), was reported previously (Melis, 1999; Oliveira-Filho et al., 1989). However, the ethanolic extract tested in our study showed no adverse effect on the testes (Supplementary Fig. S1).
In vitro bioassay investigations of the endocrine disrupting potential of steviol glycosides and their metabolite steviol, components of the natural sweetener Stevia
2016, Molecular and Cellular EndocrinologyCitation Excerpt :The current study revealed no agonist response in any of the RGA cell lines for all compounds tested, however an antagonist response was observed in the progesterone responsive TM-Luc cell line whereby 25,000 ng/ml steviol induced a 28.1% decrease in the progesterone receptor nuclear transcriptional activity. In agreement with these findings, a study by Oliveira-Filho et al. (1989) reported that the number of binding sites for androgens were not altered in rats chronically administered Stevia rebaudiana extract. However, effects on the androgen receptor have previously been highlighted by Uehara et al. (1982) who demonstrated that purified stevioside displaced 5a-dihydrotestosterone specifically bound to prostate androgen receptors in vitro (Uehara et al., 1982).
A systematic review of medicinal plants used for weight loss in Brazil: Is there potential for obesity treatment?
2015, Journal of EthnopharmacologyCitation Excerpt :Kujur et al. (2010) observed the reduction of glycemia in diabetic rats treated with the extract of the leaves (2 g/kg) of stevia. However, no effect was observed by Oliveira-Filho et al. (1989) on glycemia, body weight, thyroxine (T4) and triiodothyronine (T3) concentrations or other endocrine parameters in rats chronically treated with the aqueous extracts of the leaves of S. rebaudiana. Concerning the other species identified in the present study, although they were cited in ethnobotanical studies to be useful for the treatment of obesity and overweight, it was not verified scientifically whether they were effective in the treatment of obesity or other conditions such as hyperglycemia or dyslipidemias.
Stevioside and related compounds: Therapeutic benefits beyond sweetness
2009, Pharmacology and TherapeuticsRebaudioside A: Two-generation reproductive toxicity study in rats
2008, Food and Chemical Toxicology