Long-term potentiation of C-fiber-evoked potentials in the rat spinal dorsal horn is prevented by spinal N-methyl-d-aspartic acid receptor blockage
References (12)
- et al.
Controlled superfusion of the rat spinal cord for studying non-synaptic transmission: an autoradiographic analysis
J Neurosci. Methods
(1995) - et al.
Evidence for a role of the NMDA receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurones following C fibre stimulation
Neuropharmacology
(1987) Pain and hyperalgesia following tissue injury: new mechanisms and new treatments
Pain
(1991)- et al.
Activity-dependent neuronal plasticity following tissue injury and inflammation
Trends Neurosci.
(1992) - et al.
Evidence for spinal N-methyl-d-aspartate receptor involvement in prolonged chemical nociception in the rat
Brain Res.
(1990) Postsynaptic factors control the duration of synaptic enhancement in area CA1 of the hippocampus
Neuron
(1991)
Cited by (254)
Long-term reversal of chronic pain behavior in rodents through elevation of spinal agmatine
2023, Molecular TherapyEffect of sympathetic sprouting on the excitability of dorsal root ganglion neurons and afferents in a rat model of neuropathic pain
2022, Biochemical and Biophysical Research CommunicationsNeuropathic pain modeling: Focus on synaptic and ion channel mechanisms
2021, Progress in NeurobiologyBulleyaconitine A Inhibits Itch and Itch Sensitization Induced by Histamine and Chloroquine
2020, NeuroscienceCitation Excerpt :An analog-to-digital converter card (ADC-42 PICO) was used to digitize and store data at a sampling rate of 10 kHz. The strength of the test stimulation (0.5-ms duration, every 1 min) was adjusted to 1.5–2 times of threshold for C-fiber response (Liu and Sandkühler, 1995; Zhu et al., 2015). The amplitudes of the C-fiber evoked field potentials were determined online using the LTP program (www.ltp-program.com).
Microglia Are Indispensable for Synaptic Plasticity in the Spinal Dorsal Horn and Chronic Pain
2019, Cell ReportsCitation Excerpt :This is difficult to achieve, largely because of the complexity in synaptic connections and functions of the hippocampus. On the other hand, spinal LTP at C-fiber (pain fiber) synapses (Liu and Sandkühler, 1995) is believed to be a pain memory that may underlie some forms of chronic pain (Liu and Zhou, 2015). The present work provides evidence supporting the hypothesis that induction of LTP at synapses between afferent C-fibers and dorsal horn neurons by 10 V HFS is associated with mechanical allodynia lasting for 50 days in rats (Figure S2B) and more than 35 days in mice (Figure 4E) as well as thermal hyperalgesia for around 14 days (Figure 1H).