Integration of biomaterials implanted into abdominal wall: process of scar formation and macrophage response

doi:10.1016/0142-9612(95)98855-8

Biomaterials

Volume 16, Issue 5, 1995, Pages 381-387

https://doi.org/10.1016/0142-9612(95)98855-8 Get rights and content

Abstract

The behaviour of two biomaterials polytetrafluoroethylene (PTFE) and polypropylene (PL) has been studied, focussing especially on the macrophage response to the implant, as well as on certain aspects of the process of scar formation. A total of 24 animals (white New Zealand rabbits) received prostheses implanted into the anterior abdominal wall in such a way as to involve every layer over an area of 7cm × 5cm. The interfaces formed with the visceral peritoneum, subcutaneous tissue layer and the recipient muscle-aponeurotic tissue were assessed. The techniques employed were light microscopy, scanning electron microscopy and immunohistochemical methods, the latter using a monoclonal antibody specific for rabbit macrophages (RAM-11). From the results obtained, it can be seen that: (a) the structure of PL allows its total integration with the reparative tissue, while PTFE becomes encapsulated, on both the subcutaneous and the peritoneal aspects, by orderly connective tissue; (b) the macrophage response, determined on the basis of the presence of labelled macrophages, shows a similar pattern in both biomaterials; and (c) angiogenesis is very intense in the PL mesh, whereas the PTFE prosthesis undergoes almost no vascular colonization.

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Integration of biomaterials implanted into abdominal wall: process of scar formation and macrophage response

Abstract

J Surg Res

Expanded polytetrafluoroethylene patch for the repair of large abdominal wall defects

Br J Surg

Massive incisional hernia: abdominal wall replacement with Marlex mesh

Br J Surg

A comparison of polypropylene mesh, expanded polytetrafluoroethylene patch and polyglycolic acid mesh for the repair of experimental abdominal wall defects

Acta Chir Scand

Attachment of indium-111 labelled endothelial cells to pretreated polytetrafluoroethylene vascular grafts

Br J Surg

A comparison of intraperitoneal prostheses for the repair of abdominal muscular wall defects in rats

Eur Surg Res

A comparison of polypropylene mesh and expanded polytetrafluoroethylene patch for the repair of contaminated abdominal wall defects. An experimental study

Surgery

The risk of reherniation in the repair of abdominal wall defects. Polypropylene mesh versus expanded polytetrafluoroethylene

The role of the macrophage in wound repair

Am J Pathol