Cell
MinireviewCellular processing of β-amyloid precursor protein and the genesis of amyloid β-peptide
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2022, Molecular TherapyCitation Excerpt :Finally, we sought to determine the applicability for base editing cis-acting sequences as an approach for perturbing target gene expression. To this end, we targeted the promoter region of the gene encoding the amyloid precursor protein (APP), a transmembrane protein whose cleavage results in the peptide fragments that comprise amyloid β (Aβ),68 a protein contained within the amyloid plaques that are considered a hallmark of Alzheimer’s disease (AD).69 Rather than relying on a CRISPRi tiling screen to identify functional non-coding regions for targeting by base editing, we used a priori knowledge of the human APP promoter to design three CBE systems whose editing windows overlapped with (1) a single conserved cytosine within a predicted binding site for the TF HSF1 (CBE-A) or (2) multiple cytosines within GGGCGC boxes spanning −333 to −255 bp from the translation start codon (CBE-B and -C), which have been shown to be important for modulating APP expression (Figure 4A).70,71,72,73
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