Cell
Volume 65, Issue 7, 28 June 1991, Pages 1143-1152
Journal home page for Cell

Article
A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations

https://doi.org/10.1016/0092-8674(91)90010-VGet rights and content

Abstract

To elucidate the molecular biology of the hematopoietic stem cell, we have begun to isolate genes from murine cell populations enriched in stem cell activity. One such cDNA encodes a novel receptor tyrosine kinase, designated fetal liver kinase-2 or flk-2, which is related to the W locus gene product c-kit. Expression analyses suggest an extremely restricted distribution of flk-2. It is expressed in populations enriched for stem cells and primitive uncommitted progenitors, and is absent in populations containing more mature cells. Therefore, this receptor may be a key signal transducing component in the totipotent hematopoietic stem cell and its immediate self-renewing progeny.

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