Neuronal plasticity in aging: a quantitative immunohistochemical study of GAP-43 distribution in discrete regions of the rat brain
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Sex differences in maternal odor preferences and brain levels of GAP-43 and sonic hedgehog proteins in infant SHR and Wistar Kyoto rats
2023, Behavioural Brain ResearchCitation Excerpt :Considering that the neuronal complexity in several areas of the postnatal brain, which includes the hippocampus maturation has been associated with increased levels of Shh [58,59], we speculate that these behavioral alterations observed in infant SHR may be associated with decreased levels of Shh. Regarding GAP-43, this protein is highly expressed in the CNS during the perinatal period and gradually decreases in some mature brain areas [60,61]. While GAP-43 has remained unchanged in early infancy, its levels increased over time in the frontal cortex in all animals, but it was higher in male SHR, and in some extension in the hippocampus (PND 22).
Restored presynaptic synaptophysin and cholinergic inputs contribute to the protective effects of physical running on spatial memory in aged mice
2019, Neurobiology of DiseaseCitation Excerpt :GAP-43 is a presynaptic membrane phosphoprotein, contributing to plasticity and growth of the presynaptic terminal that may occur during the formation of memory (Aigner et al., 1995; Skene, 1989). During the aging process, decreased expression of GAP-43 has been observed in the hippocampus (Chao et al., 1992; Casoli et al., 1996). In the current study, age-related loss of individual GAP-43-ir puncta was found in area CA1 and DG.
A single high dose of dexamethasone increases GAP-43 and synaptophysin in the hippocampus of aged rats
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