Single and multiple desipramine exposures of cultured cells: Changes in cellular anisotropy and in lipid composition of whole cells and of plasma membranes
References (28)
- et al.
Subcellular distribution of the antidepressant drug desipramine in cultured human fibroblasts after chronic administration
Biochem Pharmacol
(1987) - et al.
Inhibition of phospholipid degradation and changes of the phospholipid pattern by desipramine in cultured human fibroblasts
Biochem Pharmacol
(1983) - et al.
Lipidosis induced by amphiphilic cationic drugs
Biochem Pharmacol
(1978) - et al.
Chronic exposure of human cells in culture to the tricyclic antidepressant desipramine reduces the number ofβ-adrenoceptors
Biochem Pharmacol
(1986) - et al.
Organ-specific, qualitative changes in phospholipid composition of rats after chronic administration of the antidepressant drug desipramine
Biochem Pharmacol
(1988) - et al.
An assessment of the fluidity gradient of the lipid bilayer as determined by a set of n-(9-anthroyloxy) fatty acids (n = 2, 6, 9, 12, 16)
J Biol Chem
(1979) - et al.
Steady-state fluorescence polarization in planar lipid membranes
Biophys Chem
(1982) - et al.
Plasma membrane fluidity measurements on whole living cells by fluorescence anisotropy of timethyl-ammoniumdiphenylhexatriene
Biochim Biophys Acta
(1985) - et al.
The use of n-(9-anthroyloxy) fatty acids to determine fluidity and polarity gradients in phospholipid bilayers
Biochim Biophys Acta
(1979) - et al.
Lipid phase transitions and drug interactions
Biochim Biophys Acta
(1974)
Influence of various cationic amphiphilic drugs on the phase transition temperature of phosphatidylcholine liposomes
Biochem Pharmacol
Drug-induced phospholipidosis
Germ Med
Studies on the mechanism of phospholipid storage induced by amantadine and chloroquine in madin darby canine kidney cells
Biochem Pharmacol
Lipid fluidity markedly modulates the binding of serotonin to mouse brain membranes
Cited by (26)
St John's wort extract influences membrane fluidity and composition of phosphatidylcholine and phosphatidylethanolamine in rat C6 glioblastoma cells
2019, PhytomedicineCitation Excerpt :Chronic incubation of C6 cells with the antidepressants DMI and citalopram revealed no changes of the PC/PE ratio within whole cell lipid extracts, as suggested by the absence of a change in TMA-DPH fluorescence anisotropy. Interestingly, in rat ROC-1 cells exposed for several days to a high concentration of DMI a decrease in the PC/PE ratio was demonstrated, while human fibroblasts under identical conditions showed the opposite effect (Toplak et al., 1990). Another similar in vivo study also determined a non-significant change of the PC/PE ratio in brain homogenates, following daily i.p. injections (21 days) of DMI to rats (Moor et al., 1988).
Human cells and cell membrane molecular models are affected in vitro by chlorpromazine
2008, Biophysical ChemistryChemical genetic screening identifies tricyclic compounds that decrease cellular melanin content
2008, Journal of Investigative DermatologyCitation Excerpt :For example, imipramine induces lysosomal accumulation of cholesterol by blocking the postlysosomal transport of cholesterol (Roff et al., 1991; Palmeri et al., 1992; Sato et al., 1998). Honegger et al. have reported that chronic desipramine exposure results in alteration of the cellular and membranous phospholipid patterns (Toplak et al., 1990) and promotes lysosomal phospholipid accumulation (Honegger et al., 1983). The same group later reported that chronic exposure to desipramine also impairs β1-adrenoceptor recycling in rat C6 glioblastoma cells through a modulation of receptor trafficking pathways (Bürgi et al., 2003).
Antidepressant-induced switch of β<inf>1</inf>-adrenoceptor trafficking as a mechanism for drug action
2003, Journal of Biological ChemistryCitation Excerpt :As shown for mannose 6-phosphate receptors by Gonzalez-Noriega et al. (56), definitive fate decisions may be made as late as 3–4 h after internalization, because receptors could still be salvaged within this time period, whereas intervention at later time points could not prevent degradation in the lysosomal compartment anymore. We previously reported that chronic DMI exposure results in alterations of the cellular and membranous phospholipid patterns (11) and promotes lysosomal phospholipid accumulation (57). The modification of the physicochemical membrane characteristics does not interfere with receptor binding and internalization.
The role of lysosomes in the cellular distribution of thioridazine and potential drug interactions
1999, Toxicology and Applied PharmacologyInsulin resistance and membrane abnormalities
1995, The Lancet