Kinetics and mechanism of uptake of platinum-based pharmaceuticals by the rat small intestine
References (20)
A new reagent for the determination of sugars
J Biol Chem
(1945)Fundamental studies with cisplatin
Cancer
(1983)- et al.
Second generation anticancer platinum compounds
Chem Brit
(1986) - et al.
Early clinical studies with cis-diammine-1,1 -cyclobutane dicarboxylate platinum II
Cancer Chemother Pharmacol
(1982) - et al.
Antitumour, pharmacokinetic and toxicity studies with orally administered cisplatin, CBDCA and CHIP
- et al.
A comparative study of cisplatin toxicity and route of administration
Biochem Soc Trans
(1986) - et al.
Antitumour effect of oral cisplatin on certain murine tumours
Chem Pharm Bull
(1985) - et al.
Method for studying intestinal metabolism and absorption
J Physiol
(1953) - et al.
A method of studying the intestinal absorption of aluminium in the rat
Arch Toxicol
(1984) - et al.
The effect of Di-and Trivalent iron on the intestinal absorption of aluminium in rats
Toxicol Appl Pharmacol
(1987)
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