Biochemical and Biophysical Research Communications
Formation of phosphatidylethanol in rat brain by phospholipase D
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Phosphatidylethanol (B-PEth) and other direct and indirect biomarkers of alcohol consumption
2024, International Review of NeurobiologyDevelopment and validation of an LC-MS/MS method to quantify the alcohol biomarker phosphatidylethanol 16:0/18:1 in dried blood spots for clinical research purposes
2023, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life SciencesPhosphatidylethanol in patients with liver diseases of different etiologies: Analysis of six homologues and comparison with other alcohol markers
2022, Clinica Chimica ActaCitation Excerpt :Phosphatidylethanol (PEth) is an abnormal phospholipid consisting of a phosphoethanol headgroup with a variety of fatty acid chains attached to a glycerol backbone. Because PEth production by the enzyme phospholipase D requires the presence of ethanol [7], it can be used as a direct alcohol marker. Previously, it was reported to have a sensitivity and specificity of 73–100% and 90–96%, respectively to determine any alcohol consumption in the previous one to four weeks [6].
Determination of the alcohol biomarker phosphatidylethanol 16:0/18:1 and 33 compounds from eight different drug classes in whole blood by LC-MS/MS
2021, Journal of Pharmacological and Toxicological MethodsAn automated sample preparation approach for routine liquid chromatography tandem-mass spectrometry measurement of the alcohol biomarkers phosphatidylethanol 16:0/18:1, 16:0/16:0 and 18:1/18:1
2019, Journal of Chromatography ACitation Excerpt :PEths are a group of aberrant phospholipids formed in the membranes of erythrocytes when alcohol is present. The ubiquitous enzyme phospholipase D (PLD) catalyzes the transphosphatidylation reaction between ethanol and phosphatidylcholine (PC) [8–10]. Consequently, PEths may also be generated postsampling (in vitro) in blood samples containing ethanol [11–13].