Experimental Study of Plastic Material as Replacement for the Cornea*: A Preliminary Report
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The historical development and an overview of contemporary keratoprostheses
2022, Survey of OphthalmologyCitation Excerpt :Salzer suggested that future prostheses should be made of materials lighter than glass and contain an outer rim of material that would easily integrate into the host's tissue.22 It was not until the introduction of nontoxic plastics such as polymethylmethacrylate (PMMA) in the 1950s that the successful implantation of keratoprosthesis was reported.105 Improved postoperative management with antibiotics and steroids also likely contributed to successful device implantation.98
Stem cell-based therapeutic strategies for corneal epithelium regeneration
2021, Tissue and Cell3D bioprinting for artificial cornea: Challenges and perspectives
2019, Medical Engineering and PhysicsCitation Excerpt :Artificial cornea has several significant advantages over donor corneas as show in the Table 1. In the mid-20th century, with the development of new materials with transparent, non-toxic and well mechanical properties along with the introduction of antibiotics, topical corticosteroids and immunosuppressive agents [32] enabling better postoperative management, some keratoprostheses were reported to be used as artificial replacements for the opaque or damaged corneas [33–38]. Up to now, there are six well-developed keratoprosthesis (Table 2): the modified osteo-odonto-keratoprosthesis (OOKP) [44], the Boston type I keratoprosthesis (B-KPro Type I), AlphaCorTM keratoprosthesis [80,81], the Boston type II keratoprosthesis (B-KPro Type II) [77], Seoul-type keratoprosthesis [87–89], KeraKlear®-Keratoprothese (Keramed Inc.).
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From the Massachusetts Eye and Ear Infirmary and the Massachusetts General Hospital. This work was supported in part by the Office of Naval Research, Nonr469(00)- NR 115-163 and by the National Society for the Prevention of Blindness