Current concepts in the pathogenesis of the obesity-hypoventilation syndrome: Mechanical and circulatory factors☆
References (75)
A peculiar type of cardiopulmonary failure associated with obesity
Am J Med
(1956)- et al.
The determination of gases in blood and other solution by vacuum extraction and manometric measurement
J Biol Chem
(1924) - et al.
Corrections for plasma trapped in the red cell column of the hematocrit
Blood
(1952) - et al.
The thorax in chronic obstructive lung disease
Am J Med
(1968) - et al.
Defect in automatic respiration in a case of multiple sclerosis
Am J Med
(1974) Obesity and cardiac performance
Am J Cardiol
(1964)- et al.
Influence of chronic pulmonary disease on the heart and circulation
Am J Med
(1951) - et al.
Hypoventilatton and heart disease
Lancet
(1961) - et al.
A reconsideration of the origins of pulmonary hypertension
Chest
(1971) - et al.
Observations on some clinical features of extreme obesity, with particular reference to cardiorespiratory effects
Am J Med
(1962)
Clinical and physiological aspects of a case of obesity, polycythemia and alveolar hypoventilatton
J Clin Invest
Extreme obesity associated with alveolar hypoventilation: a Pickwickian syndrome
Am J Med
The respiratory effects of extreme obesity
Can Med Assoc J
Pulmonary function in obese persons
J Clin Invest
Hypoventilation in obesity
J Clin Invest
Syndrome of extreme obesity and hypoventilation: studies of etiology
Ann Intern Med
The efficiency of ventilation during voluntary hyperpnea: studies in normal subjects and in dyspneic patients with either chronic pulmonary emphysema or obesity
J Clin Invest
Compliance of the respiratory system in health and obesity
J Appl Physiol
The effect of change in body position on lung volumes and intrapulmonary gas mixing in patients with obesity, heart failure and emphysema
Am Rev Respir Dis
Abnormalities of pulmonary gas exchange in obesity
Ann Intern Med
The oxygen cost and work of breathing in normal and obese subjects
S Afr J Lab Clin Med
The efficiency of the respiratory muscles in obesity
Can J Btochem Physiol
The respiratory defects In extreme obesity
Am J Med
Total respiratory inertance and its gas and tissue components in normal and obese men
J Clin Invest
The total work of breathing in normal and obese men
J Clin Invest
Syndrome of alveolar hypoventilation and diminished sensitivity of the respiratory center
N Engl J Med
Idiopathic hypoventilation
JAMA
Pulmonary function in the obese patient
Am J Med Sci
The effects of weight reduction on pulmonary function and the sensitivity of the respiratory center in obesity
Am Rev Respir Dis
A study of the pulmonary blood volume in man by quantitative radiocardiography
J Clin Invest
Determinants of pulmonary blood volume
J Clin Invest
Obesity associated with cardiopulmonary failure; the Pickwickian syndrome
Acta Med Scand
Diaphragm activity in obesity
J Clin Invest
Quantitative radiocardiography. II. Technique and analysis of curves
Circulation
Blood volume in clinical shock. I. Mixing time and disappearance rate of T-1824 in normal subjects and in patients In shock. Determinations of plasma volume in man from 10-minute sample
J Clin Invest
Body/venous hematocrit ratio: its constancy over a wide hematocrit range
J Clin Invest
Cited by (211)
Obesity Hypoventilation Syndrome
2020, Neurological Modulation of Sleep: Mechanisms and Function of Sleep HealthThe effects of weight loss, tracheostomy, and medication on obesity hypoventilation syndrome
2020, Obesity Hypoventilation Syndrome: From Physiologic Principles to Clinical PracticeThe pathophysiology of obesity hypoventilation syndrome
2020, Obesity Hypoventilation Syndrome: From Physiologic Principles to Clinical PracticeObesity hypoventilation in the intensive care unit
2020, Obesity Hypoventilation Syndrome: From Physiologic Principles to Clinical PracticeAn act of balance: Interaction of central and peripheral chemosensitivity with inflammatory and anti-inflammatory factors in obstructive sleep apnoea
2019, Respiratory Physiology and NeurobiologyCitation Excerpt :This opens the question, how obesity is able to influence chemosensitivity resulting in such different outcomes in ventilatory responses to hypoxia and hypercapnia in connection with OSA and OHS? In obesity, mechanical factors may play a role with oxygen cost of breathing increased in combination with reduced forced vital capacity (FVC) (Rochester and Enson, 1974). However, the variability of the ventilatory response to hypoxia and hypocapnia in OSA suggests more complex mechanisms, which might involve changes of central and peripheral chemosensitivity.
- ☆
This work was supported in part by U.S. Public Health Service Grants HL 02001 and HL 05443, and by grants from the New York Heart Association, The Stonywold Foundation and the Health Research Council of the City of New York.
- 1
From the Department of Medicine, Columbia University, College of Physicians and Surgeons, and the Medical Service, Harlem Hospital Center, New York, New York.