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Immune-Related Adverse Events Associated with Immune Checkpoint Inhibitors

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Abstract

Immune checkpoint inhibitors (ICIs), including antibodies targeting cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and programmed cell death protein-1 (PD-1), have shown durable treatment responses in multiple tumor types by enhancing antitumor immunity. However, removal of self-tolerance can induce autoimmunity and produce a unique immune-driven toxicity profile, termed immune-related adverse events (irAEs). As ICIs gain approval for a growing number of indications, it is imperative clinicians increase their knowledge of and ability to manage irAEs. This review examines the etiology, presentation, kinetics, and treatment of irAEs and aims to provide practical guidance for clinicians.

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Correspondence to Aaron R. Hansen.

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Daphne Day and Aaron R. Hansen have no conflicts of interest.

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Daphne Day is an OICR (Ontario Institute of Cancer Research) Research Fellow and is supported by the Ontario Institute for Cancer Research through funding provided by the Government of Ontario.

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Day, D., Hansen, A.R. Immune-Related Adverse Events Associated with Immune Checkpoint Inhibitors. BioDrugs 30, 571–584 (2016). https://doi.org/10.1007/s40259-016-0204-3

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