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The impact of caveolin protein expression in tumor stroma on prognosis of breast cancer

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Tumor Biology

Abstract

We aimed to investigate the expression of caveolin-1, -2, -3, and platelet-derived growth factor (PDGF) β receptor in breast cancer cells and stroma by immunohistochemistry and to analyze their implications. The expression rates of stromal caveolin-2 and PDGF β receptor increased as the tumor progressed from ductal carcinoma in situ to microinvasive ductal carcinoma, intraductal component of invasive ductal carcinoma (IDC), and IDC (p < 0.001). The expression loss of caveolin-1 in tumor stroma of IDC correlated with high tumor stage (p < 0.001), high nodal stage (p = 0.011), high cancer stage (p = 0.005), estrogen receptor negativity (p = 0.003), and tumor recurrence (p = 0.003). In addition, the expression loss of caveolin-1 in tumor stroma was correlated with a shorter disease-free survival and an overall survival (p < 0.001). In conclusion, the loss of stromal caveolin-1 is related to poor prognosis in IDC.

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Authors and Affiliations

  1. Department of Pathology, Yonsei University College of Medicine, Seoul, South Korea

    Ja Seung Koo & Sarah Lee

  2. Department of Surgery, Severance Hospital, Yonsei University College of Medicine, 250 Seongsanno Seodaemun-gu, Seoul, South Korea

    Seho Park, Seung Il Kim & Byeong-Woo Park

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  1. Ja Seung Koo
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  2. Seho Park
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  3. Seung Il Kim
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  4. Sarah Lee
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  5. Byeong-Woo Park
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Correspondence to Byeong-Woo Park.

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Koo, J.S., Park, S., Kim, S.I. et al. The impact of caveolin protein expression in tumor stroma on prognosis of breast cancer. Tumor Biol. 32, 787–799 (2011). https://doi.org/10.1007/s13277-011-0181-6

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  • DOI: https://doi.org/10.1007/s13277-011-0181-6

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