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Sentinel Lymph Node Biopsy in Breast Cancer: Current Status and Recent Progress

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Indian Journal of Surgery Aims and scope Submit manuscript

Abstract

Sentinel lymph node biopsy (SLNB) is a standard procedure used to evaluate the status of axillary lymph nodes (ALNs) that are clinically tumor-free in patients with early-stage breast cancer. Recent research on SLNB has led to continual improvements in the scope of application, accuracy in information provided, and relevance of the results for subsequent treatment. This review is based on selective searches of the Springer Publishing Company and PubMed databases for articles about progress and developments of SLNB in patients with breast cancer. The main purposes are to summarize the current status and established indications for SLNB, identify specific topics that are still under debate, and suggest specific areas where further studies are most needed.

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References

  1. Desantis CE, Bray F, Ferlay J et al (2015) International variation in female breast cancer incidence and mortality rates.[J]. Cancer Epidemiol Biomark Prev 24(10):1495–1506

    Article  Google Scholar 

  2. Gherghe M, Bordea C, Blidaru A (2014) Sentinel lymph node biopsy (SLNB) vs. axillary lymph node dissection (ALND) in the current surgical treatment of early stage breast cancer.[J]. J Med Life 8(2):176–180

    Google Scholar 

  3. Goldhirsch A, Ingle JN, Gelber RD et al (2009) Thresholds for therapies: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2009[J]. Ann Oncol 20(8):1319–1329(11)

    Article  CAS  Google Scholar 

  4. Faries MB, Bedrosian I, Reynolds C et al (2000) Active macromolecule uptake by lymph node antigen-presenting cells: a novel mechanism in determining sentinel lymph node status [J]. Ann Surg Oncol 7(2):98–105

    Article  CAS  Google Scholar 

  5. Manca G, Tardelli E, Rubello D, Gennaro M, Marzola MC, Cook GJ, Volterrani D (2016) Sentinel lymph node biopsy in breast cancer: a technical and clinical appraisal.[J]. Nucl Med Commun 37:570–576

    Article  Google Scholar 

  6. Motomura K (2015) Sentinel node biopsy for breast cancer: past, present, and future.[J]. Breast Cancer 22:1–9

    Article  Google Scholar 

  7. Palesty JA, Foster JM, Hurd TC et al (2006) Axillary recurrence in women with a negative sentinel lymph node and no axillary dissection in breast cancer [J]. J Surg Oncol 93(2):129–132

    Article  Google Scholar 

  8. Janni W, Kühn T, Schwentner L, Kreienberg R, Fehm T, Wöckel A (2014) Sentinel node biopsy and axillary dissection in breast cancer: the evidence and its limits [J]. Dtsch Arztebl Int 111(14):244–249

    PubMed  PubMed Central  Google Scholar 

  9. Soares EWS, Nagai HM, Bredt LC et al (2014) Morbidity after conventional dissection of axillary lymph nodes in breast cancer patients [J]. World J Surg Oncol 12(1):1–8

    Article  Google Scholar 

  10. Veronesi U, Paganelli G, Viale G et al (2003) A randomized comparison of sentinel-node biopsy with routine axillary dissection in breast cancer [J]. N Engl J Med 349(6):546–553

    Article  Google Scholar 

  11. Lyman GH, Giuliano AE, Somerfield MR et al (2005) American Society of Clinical Oncology guideline recommendations for sentinel lymph node biopsy in early-stage breast cancer [J]. J Clin Oncol 23(30):7703

    Article  Google Scholar 

  12. Krag DN, Anderson SJ, Julian TB et al (2007) Technical outcomes of sentinel-lymph-node resection and conventional axillary-lymph-node dissection in patients with clinically node-negative breast cancer: results from the NSABP B-32 randomised phase III trial : The Lancet Oncology [J]. Lancet Oncol 8(10):881–888

    Article  CAS  Google Scholar 

  13. Lyman GH, Temin S, Edge SB, Newman LA, Turner RR, Weaver DL, Benson AB 3rd, Bosserman LD, Burstein HJ, Cody H 3rd, Hayman J, Perkins CL, Podoloff DA, Giuliano AE (2014) American Society of Clinical Oncology Clinical Practice. Sentinel lymph node biopsy for patients with early-stage breast cancer: American Society of Clinical Oncology clinical practice guideline update.[J]. J Clin Oncol 32(13):1365–1383

    Article  Google Scholar 

  14. Taguchi Y, Yasojima H, Masuda H et al (2014) 171. The long-term prognosis of sentinel lymph node-positive breast cancer patients without axillary dissection [J]. Clin Orthop Relat Res 40(11):1–31

    Google Scholar 

  15. Giuliano AE, Ballman KV, Mccall L et al (2017) Effect of axillary dissection vs no axillary dissection on 10-year overall survival among women with invasive breast cancer and sentinel node metastasis: the ACOSOG Z0011 (Alliance) randomized clinical trial.[J]. JAMA 318(10):918

    Article  Google Scholar 

  16. Giuseppe Canavese MD, Paolo Bruzzi MD…. Sentinel Lymph Node Biopsy Versus Axillary Dissection in Node-Negative Early-Stage Breast Cancer: 15-Year Follow-Up Update of a Randomized Clinical Trial[J]. Annals of Surgical Oncology, 23(8):2494–2500.

    Article  Google Scholar 

  17. Bilimoria KY, Bentrem DJ, Hansen NM et al (2009) Comparison of sentinel lymph node biopsy alone and completion axillary lymph node dissection for node-positive breast cancer [J]. J Clin Oncol 27(18):2946–2953

    Article  Google Scholar 

  18. (2017) Sentinel lymph node biopsy for patients with early stage breast cancer: American Society of Clinical Oncology clinical practice guideline update. J Clin Oncol 35(5):561–564. https://doi.org/10.1200/JCO.2016.71.0947

    Article  Google Scholar 

  19. Meretoja T, Leidenius et al (2013) Re: International multicenter tool to predict the risk of nonsentinel;node metastases in breast cancer response [J]. J Natl Cancer Inst 105(19):1514–1514

    Article  Google Scholar 

  20. Maimaitiaili A, Wu D, Liu Z, Liu H, Muyiduli X, Fan Z. Analysis of factors related to non-sentinel lymph node metastasis in 296 sentinel lymph node-positive Chinese breast cancer patients [published correction appears in Cancer Biol Med. 2018 Nov;15(4):478].Cancer Biol Med. 2018;15(3):282–289. doi:10.20892/j.issn.2095–3941.2018.0023

  21. Dingemans SA, Rooij PD, van der Vuurst de Vries RM et al (2016) Validation of six nomograms for predicting non-sentinel lymph node metastases in a Dutch breast cancer population [J]. Ann Surg Oncol 23(2):477–481

    Article  Google Scholar 

  22. Melissa Pilewskie, Maria Karsten, Julia Radosa, et al. Is Sentinel Lymph Node Biopsy Indicated at Completion Mastectomy for Ductal Carcinoma In Situ?[J]. Annals of Surgical Oncology, 2016:1-6.

  23. Roozendaal LMV, Goorts B, Klinkert M et al (2016) Sentinel lymph node biopsy can be omitted in DCIS patients treated with breast conserving therapy [J]. Breast Cancer Res Treat 156:517–525

    Article  Google Scholar 

  24. Krontiras H, Bland KI (2003) When is sentinel node biopsy for breast cancer contraindicated?[J]. Surg Oncol 12(3):207–210

    Article  Google Scholar 

  25. Gropper AB, Calvillo KZ, Dominici L et al (2014) Sentinel lymph node biopsy in pregnant women with breast cancer.[J]. Ann Surg Oncol 21(8):2506–2511

    Article  Google Scholar 

  26. Han S N , Amant F , Sangalli C , et al. 266pd_prsentinel lymph node biopsy for breast cancer treatment during pregnancy - on behalf of the international network of cancer, infertility and pregnancy (incip) and the german breast group (gbg)[j]. Annals of Oncology, 2014, 25(4 (Supplement)).

  27. Hunt KK (2009) Is sentinel lymph node biopsy after neoadjuvant chemotherapy feasible and accurate in women with advanced breast cancer?[J]. Curr Breast Cancer Rep 1(2):65–67

    Article  Google Scholar 

  28. Mamtani, Anita, Barrio, Andrea V, King, Tari A,et al. How Often Does Neoadjuvant Chemotherapy Avoid Axillary Dissection in Patients With Histologically Confirmed Nodal Metastases? Results of a Prospective Study[J]. Annals of Surgical Oncology, 23(11):3467-3474.

    Article  Google Scholar 

  29. Thorsten K, Ingo B, Tanja F et al (2013) Sentinel-lymph-node biopsy in patients with breast cancer before and after neoadjuvant chemotherapy (SENTINA): a prospective, multicentre cohort study [J]. Lancet Oncol 14(7):609–618

    Article  Google Scholar 

  30. Gallant E, Ewing C, Wong J, et al. Abstract P3-01-10: Sentinel lymph node biopsy after neoadjuvant chemotherapy for patients with clinically node-positive breast cancer: A single institution retrospective evaluation[J]. 2016, 76(4 Supplement):P3-01-10-P3-01-10.

  31. Kashiwagi S, Onoda N, Asano Y et al (2015) Ambulatory sentinel lymph node biopsy preceding neoadjuvant therapy in patients with operable breast cancer: a preliminary study [J]. World J Surg Oncol 13(1):1–6

    Article  Google Scholar 

  32. Caudle AS, Yang W, Mittendorf EA, et al. Targeted axillary dissection improves axillary evaluation following neoadjuvant chemotherapy in node positive patients [C]// Cancer Symposium of the Society-Of-Surgical-Oncology. 2015:S6–S6.

  33. Ahmed M , Douek M . Targeted axillary dissection after neoadjuvant therapy in breast cancer[J]. British Journal of Surgery, 2017.

  34. Tomasz N, Andrzej K, Wojciech P et al (2016) Imaging methods for the local lymphatic system of the axilla in early breast cancer in patients qualified for sentinel lymph node biopsy:[J]. Menopausal Rev 15(1):52–55

    Google Scholar 

  35. Iii HSC, Fey J, Akhurst T et al (2001) Complementarity of blue dye and isotope in sentinel node localization for breast cancer: univariate and multivariate analysis of 966 procedures [J]. Ann Surg Oncol 8(1):13–19

    Article  Google Scholar 

  36. Hung WK, Chan CM, Ying M et al (2006) Randomized clinical trial comparing blue dye with combined dye and isotope for sentinel lymph node biopsy in breast cancer [J]. J Electron Microsc 92(12):1494–1497

    Google Scholar 

  37. He PS, Li F, Li GH et al (2016) The combination of blue dye and radioisotope versus radioisotope alone during sentinel lymph node biopsy for breast cancer: a systematic review [J]. BMC Cancer 16(1):1–12

    Article  Google Scholar 

  38. Sugie T, Kinoshita T, Masuda N et al (2015) Evaluation of the clinical utility of the ICG fluorescence method compared with the radioisotope method for sentinel lymph node biopsy in breast cancer [J]. Ann Surg Oncol 23(1):635–649

    Google Scholar 

  39. Ahmed M, Purushotham AD, Douek M (2014) Novel techniques for sentinel lymph node biopsy in breast cancer: a systematic review [J]. Lancet Oncol 15(8):e351–e362

    Article  Google Scholar 

  40. Deai T, Matumoto H, et al. Practice of fluorescence navigation surgery using indocyanine green for sentinel lymph node biopsy in breast cancer [M]// ICG Fluorescence Imaging and Navigation Surgery. Springer Japan, 2016.

  41. Galimberti V, Cole BF, Viale G et al (2018) Axillary dissection versus no axillary dissection in patients with breast cancer and sentinel-node micrometastases (IBCSG 23-01): 10-year follow-up of a randomised, controlled, phase 3 triall [J]. Lancet Oncol 19(10):1385–1393

    Article  Google Scholar 

  42. Galimberti V, Botteri E, Chifu C et al (2012) Can we avoid axillary dissection in the micrometastatic sentinel node in breast cancer? [J]. Breast Cancer Res Treat 131(3):819–825

    Article  Google Scholar 

  43. Gatzemeier W, Mann GB (2013) Which sentinel lymph-node (SLN) positive breast cancer patient needs an axillary lymph-node dissection (ALND) – ACOSOG Z0011 results and beyond [J]. Breast 22(3):211–216

    Article  Google Scholar 

  44. Shahkhan M, Boughey JC (2012) Evolution of axillary nodal staging in breast cancer: clinical implications of the ACOSOG Z0011 trial.[J]. Cancer Control 19(4):267–276

    Article  Google Scholar 

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We are grateful to our colleagues and their families for supporting the work.

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Correspondence to Zhimin Fan.

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Maimaitiaili, A., Liu, Z., Wu, D. et al. Sentinel Lymph Node Biopsy in Breast Cancer: Current Status and Recent Progress. Indian J Surg 82, 84–89 (2020). https://doi.org/10.1007/s12262-019-02021-z

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