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Erschienen in: memo - Magazine of European Medical Oncology 2/2022

14.04.2022 | review

Highlights ESMO 2021—lung cancer

verfasst von: Dr. Markus Rauter

Erschienen in: memo - Magazine of European Medical Oncology | Ausgabe 2/2022

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Summary

The following three abstracts presented at EESMO 2021 highlight three different areas of therapeutic strategies for non small cell lung cancer. First, neoadjuvant Atezolizumab managed to show a superior DFS compared to best supportive care in completely resected NSCLC stage II–IIIA. Second, Cemiplimab combined with chemotherapy reached the primary endpoint of OS compared to chemo alone in advanced stage IIIB/C & stage IV NSCLC patients. Third, the BEVERLY trial showed that the combination of Erlotinib with Bevacizumab in advanced EGFR-mutated NSCLC prooved to be superior to Erlotinib monotherapy in the current/former smoker subgroup, suggesting that this subgroup represents a differnt tumor biology with sprecial therapeutic needs.
Literatur
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Zurück zum Zitat Felip E, et al. Sites of relapse and subsequent therapy from a phase III study of atezolizumab vs best supportive care after adjuvant chemotherapy in stage IB–IIIA NSCLC. In: Presidential symposium 3; September 20th, 2021. Presentation LBA9. Annals of Oncology 2021;32(suppl_5):S1283–346. https://doi.org/10.1016/annonc/annonc741.CrossRef Felip E, et al. Sites of relapse and subsequent therapy from a phase III study of atezolizumab vs best supportive care after adjuvant chemotherapy in stage IB–IIIA NSCLC. In: Presidential symposium 3; September 20th, 2021. Presentation LBA9. Annals of Oncology 2021;32(suppl_5):S1283–346. https://​doi.​org/​10.​1016/​annonc/​annonc741.CrossRef
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Zurück zum Zitat Soo R. A randomized phase II study of second-line osimertinib (Osi) and bevacizumab (Bev) versus Osi in advanced non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) and T790M mutations (mt): Results from the ETOP BOOSTER trial. In: Virtual Plenary Debate; September 17th, 2021; Abstract VP3_2021. Soo R. A randomized phase II study of second-line osimertinib (Osi) and bevacizumab (Bev) versus Osi in advanced non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) and T790M mutations (mt): Results from the ETOP BOOSTER trial. In: Virtual Plenary Debate; September 17th, 2021; Abstract VP3_2021.
11.
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Metadaten
Titel
Highlights ESMO 2021—lung cancer
verfasst von
Dr. Markus Rauter
Publikationsdatum
14.04.2022
Verlag
Springer Vienna
Erschienen in
memo - Magazine of European Medical Oncology / Ausgabe 2/2022
Print ISSN: 1865-5041
Elektronische ISSN: 1865-5076
DOI
https://doi.org/10.1007/s12254-022-00801-0

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