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Erschienen in: memo - Magazine of European Medical Oncology 4/2021

21.10.2021 | ASCO 2021 | short review

Ovarian cancer—ASCO annual meeting update 2021

verfasst von: Johannes Schöche, Kathrin Strasser-Weippl

Erschienen in: memo - Magazine of European Medical Oncology | Ausgabe 4/2021

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Summary

The 2021 ASCO annual meeting did not change clinical practice in the treatment of ovarian cancer, but several interesting studies were presented that might have clinical impact in the future. One phase III study, by demonstrating no improved overall survival for an extended maintenance duration of bevacizumab treatment, supports the current standard of care of 15 months of bevacizumab for first-line maintenance. Data on Poly(ADP-ribose)-polymerase inhibitors (PARP inhibitors) again confirmed their marked clinical benefit, most prominently in certain biomarker subpopulations. Finally, new drug candidates with promising clinical activity include agents targeting ATR, Wee1, and folate receptor alpha.
Fußnoten
1
In the following, under the term “advanced ovarian cancer”, the entities epithelial ovarian, fallopian tube, and primary peritoneal cancer in International Federation of Gynecology and Obstetrics (FIGO) stages III B, III C, and IV will be subsumed.
 
2
Notably, the CBR was defined as stable disease for at least four cycles (or complete and partial remission). Attributing clinical benefit after only four cycles is arguably early—this should be considered when interpreting the study results.
 
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Metadaten
Titel
Ovarian cancer—ASCO annual meeting update 2021
verfasst von
Johannes Schöche
Kathrin Strasser-Weippl
Publikationsdatum
21.10.2021
Verlag
Springer Vienna
Schlagwort
ASCO 2021
Erschienen in
memo - Magazine of European Medical Oncology / Ausgabe 4/2021
Print ISSN: 1865-5041
Elektronische ISSN: 1865-5076
DOI
https://doi.org/10.1007/s12254-021-00772-8

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